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What makes the deadliest form of malaria specific to people?

Researchers have discovered why the parasite that causes the deadliest form of malaria only infects humans.

The team recently showed that the interaction between a parasite protein called RH5 and a receptor called basigin was essentially required for the invasion of red blood cells by the parasite that causes the deadliest form of malaria. Now, they’ve discovered that this same interaction is also an important factor in explaining why the parasite seems to be remarkably specific to humans. This research will help guide eradication strategies in regions where malaria is endemic.

There are several distinct species of parasite that cause malaria. The malaria parasite species responsible for severe illness and death, Plasmodium falciparum, only infects humans, but is closely related to several species that infect chimpanzees and gorillas.

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