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Anti-fungal drug increases flu susceptibility

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Researchers have found that a commonly used anti-fungal treatment increases susceptibility to severe influenza infection in mice. This treatment deactivates an important protein that protects against viral infections such as influenza.

Amphotericin B is an important anti-fungal treatment for people with already suppressed immune systems such as cancer patients and bone marrow transplant patients. Cells and mice treated with Amphotericin B lost the protective effects of IFITM3, a protein critical for protecting against viral infection. This increased their susceptibility to influenza infection.

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