A new way to attack flu viruses is taking shape in laboratories at Rutgers University, where scientists have identified chemical agents that block the virus’s ability to replicate itself in cell culture.
These novel compounds show promise for a new class of antiviral medicines to fight much-feared pandemic influenzas such as the looming “bird flu” threats caused by the H5N1 influenza A virus and the new H7N9 virus responsible for a 2013 outbreak in China.
Timely production of a vaccine is difficult when a pandemic flu strikes. A viable alternative is to treat with drugs.
“Right now there’s really only one effective oral drug for treating influenza,” said Eddy Arnold, Board of Governors Professor of chemistry and chemical biology in the School of Arts and Sciences at Rutgers and a member of the Center for Advanced Biotechnology and Medicine. And just as bacteria develop resistance to antibiotics, Arnold notes that some flu strains have developed resistance to Tamiflu, the sole orally available anti-flu drug.
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