MicrobeWorld App


Microbes After Hours

Click for "Microbes After Hours" videos

Featured Image

Featured Video


New from ASM Press


Join MicrobeWorld


ASM House 200X200

Subscribe via Email


Previously discovered hepatitis-associated Parvovirus-Circovirus Hybrid Presumed Laboratory Contaminant

Metagenomics has been responsible for the discovery of various novel and clinically relevant human and environmental microorganisms. However, great care must be taken with the conclusions each group makes concerning whether a novel microorganism is associated with any given disease or phenotype.
Previously, a hybrid DNA virus in Chinese patients with seronegative hepatitis was recovered by deep sequencing and termed NIH-CQV. While 63/90 patients were positive, all healthy controls were negative.
This latest paper initially identified a virus in clinical samples that shares ∼99% nucleotide and amino acid identity to NIH-CQV. However, after repeated recoveries in negative controls, the origins of the contaminating virus was traced to silica-binding spin columns used for nucleic acid extraction. They then tested ocean samples for this virus as oceanic diatoms (algae) are used to generate the silica matrix used in these spin columns. The same sequences were recovered in these samples indicating an inadvertent viral contamination during the manufacturing process.
This, just like the case of XMRV, serves as a humble lesson to all of those in the field of metagenomics.

Comments (0)

Collections (0)

No much more waiting around in line, no a lot more dealing with other customers. Purchasing requires. viagra without perscription There are many other contributory elements to low-libido and failure plus when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists have long realized that monogamy. how to get viagra samples free Kamagra Gel allows the dude to handle pfizer viagra free samples This changed mindset of individuals regarding the ailment is however not a cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL order viagra online Erection dysfunction is not just a disorder that causes problems buy female viagra online The dietary Content of Acai has amazed several of the whole buy viagra canada Ulcer is generally characterized with a sore on the exterior of the skin or a cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use