The disruption of the human microbiome through use of antimicrobials is a topic of growing interest among healthcare epidemiologists, not only because it is a major risk factor for C. difficile infection (CDI), but also because it could be a driving force behind the introduction and proliferation of multidrug-resistant organisms (MDROs) in healthcare settings. A greater understanding of the protective role of the microbiome could have major implications for the future direction of infection control. The speakers in this video review the current understanding of the role of microbiome disruption in the epidemiology of diseases such as CDI and MDRO colonization and transmission, and what the future may hold with regard to intervention.
Michael Schmidt, Medical Univ. of South Carolina, Charleston, SC
Cliff McDonald, Centers for Disease Control and Prevention, Atlanta, GA
Alan Walker, Wellcome Trust Sanger Inst., Cambridge, United Kingdom