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Multiple Mutations Often Needed to Make TB Bacteria Drug-Resistant

Tuberculosis (TB) drug resistance is not an all-or-none phenomenon, according to new research from Rutgers, The State University of New Jersey. Rather, TB-causing bacteria often accumulate mutations in a step-wise fashion, with the initial mutation having minimal impact but poising the bug to later develop high-level resistance upon acquisition of other mutations. The study appears in Nature Genetics.

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