Infection during a newborn's first 7 days of life is associated with bacterial infection or colonization in the mother. Early-onset neonatal infection, defined as infection in the first 7 days of life, is associated with maternal infection and colonization, a systematic review and meta-analysis by Grace Chan (Johns Hopkins School of Public Health) and colleagues found in this week's issue of PLOS Medicine.
Newborns of mothers with laboratory-confirmed infection had an odds ratio of 6.6 (95%CI 3.9-11.2) for laboratory-confirmed infection themselves compared with newborns of mothers without laboratory-confirmed infection. Newborns of mothers with colonization had an odds ratio of 9.4 (95%CI 3.1-28.5) of laboratory-confirmed infection compared with newborns of non-colonized mothers. Furthermore, newborns of mothers with risk factors for infection (prelabour rupture of membranes, preterm