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Drug works better if cancer can’t sleep

Keeping cancer cells from entering a state of cellular sleep makes cancer drugs more effective and lowers the chance of cancer recurrence, report researchers.

The findings, which will be published in the August 15 issue of the journal Cancer Research and are available online, are the first to show that it is possible to therapeutically target cancer cells to keep them from entering a cellular state called quiescence, or “cell sleep.”

Quiescence can be a dangerous source of tumor recurrence because cancer drugs don’t typically destroy quiescent cells.
 
 

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