MicrobeWorld App

appsquarebannerad200x200

Join MicrobeWorld

Subscribe via Email

subscribe

Microbes After Hours

MW-Site-Banner-200x200

Click for more "Microbes After Hours" videos

Featured Image

Featured Video

Crowdsourced Microbes Heading to Station

Supporters

ASM House 200X200

Multidrug resistance Pseudomonas aeruginosa

DSC01903.JPG
Pseudomonas aeruginosa is one of the most notorious organisms that have brought the therapeutic dilemmas to clinicians as well as challenge to microbiologist throughout the world. It carries gene of intrinsic resistance (AmpC cephalosporinase, the OprD outer membrane porin, and the multidrug efflux pumps) furthermore imported resistance to the lactams involves the production of inactivating lactamases enzyme and to aminoglycosides involves production of aminoglycoside-modifying enzymes and methylation of the 16S rRNA. Fluoroquinolone resistance among P. aeruginosa isolates has been linked only to chromosomal genes, with mutational changes in the fluoroquinolone targets DNA gyrase (gyrA and gyrB) and/or topoisomerase IV (parC and parE) and/or overexpression of multidrug efflux pumps.

Further information: http://cmr.asm.org/content/22/4/582.full

The isolated Pseudomonas aeruginosa was found resistance to Ceftazidime (30 mcg) Piperacillin(100mcg) Amikacin(30mcg) Aztreonam(30mcg) Cefepime(30mcg) Ciprofloaxacin(1mcg) Gentamicin(10mcg) Piperacillin /Tazobactem(100/10mcg) Imipenem (10mcg) Ofloxacin(5mcg) while sensitive to Colistin (25mcg) and Polymyxin B(300units) .

Photograph was taken in the Microbiology lab of Shree Birendra Hospital (Army Hospital) at Kathmandu, Nepal.
 
 

Comments (0)

Collections (0)

 

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use