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Circadian Rhythms Play Role In Fighting Off Intestinal Bacterial Infections: Study

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Your body clock may play a role in fighting off bacterial infections in the gut, according to a new study in animals.

Researchers said the findings could help explain why people who have disruptions in their circadian rhythm -- like those who fly across time zones frequently, or shift workers -- seem more susceptible to infections.

"Although many immune responses are known to follow daily oscillations, the role of the circadian clock in the immune response to acute infections has not been understood," study researcher Paolo Sassone-Corsi, a professor of biological chemistry at the University of California, Irvine, said in a statement. "What we’re learning is that the intrinsic power of the body clock can help fight infections."

The study, published in the journal Proceedings of the National Academy of Sciences, shows that genes controlled by the circadian rhythm seem to also affect how well the immune system responds to infection by salmonella bacteria.

"Salmonella is a good pathogen to study what happens during infection," Manuela Raffatellu, an assistant professor of microbiology and molecular genetics at the university, said in a statement. "We think these findings may be broadly applicable to other infectious diseases in the gut, and possibly in other organs controlled by circadian patterns."
 
 

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