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Metabolic Model of E. Coli Reveals How Bacterial Growth Responds to Temperature Change

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Bioengineers at the University of California, San Diego have developed a computational model of 1,366 genes in E. coli that includes 3D protein structures and has enabled them to compute the temperature sensitivity of the bacterium's proteins. The study, published June 7 in the journal Science, opens the door for engineers to create heat-tolerant microbial strains for production of commodity chemicals, therapeutic proteins and other industrial applications.

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