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New one-step process for designer bacteria

A simpler and faster way of producing designer bacteria used in biotechnology processes has been developed by University of Adelaide researchers.

The researchers have developed a new one-step bacterial genetic engineering process called ‘clonetegration’, published in the journal ACS Synthetic Biology ("One-Step Cloning and Chromosomal Integration of DNA").

Led by Dr Keith Shearwin, in the University’s School of Molecular and Biomedical Sciences, the research facilitates faster development of designer bacteria used in therapeutic drug development, such as insulin, and other biotechnology products.

Designer bacteria are produced by integrating extra pieces of genetic material into the DNA of bacteria, in this case E. coli, so that the bacteria will make a desired product.

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