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Now We Know Why Old Scizophrenia Medicine Works On Antibiotics-Resistant Bacteria

In 2008 researchers from the University of Southern Denmark showed that the drug thioridazine, which has previously been used to treat schizophrenia, is also a powerful weapon against antibiotic-resistant bacteria such as staphylococci (Staphylococcus aureus).

Antibiotic-resistant bacteria is a huge problem all over the world: For example, 25 -- 50 per cent of the inhabitants in southern Europe are resistant to staphylococci. In the Scandinavian countries it is less than 5 per cent, but also here the risk of resistance is on the rise.

So any effective anti-inflammatory candidate is important to investigate -- even if the candidate is an antipsychotic that was originally developed to alleviate one of the hardest mental illnesses, schizophrenia.

Until now, scientists could only see that thioridazine works effectively and that it can kill staphylococcus bacteria in a flask in the laboratory, but now a new study reveals why and how thioridazine works. The research group, which includes professor Hans Jørn Kolmos, associate professor Birgitte H. Kallipolitis and other participants from the Department of Biochemistry and Molecular Biology and Institute of Clinical Medicine, University of Southern Denmark, publishes their findings in the journal PLOS ONE on May 17 2013.

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