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Resistance to Visceral Leishmaniasis: New Mechanisms Involved

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Researchers from CNRS, Université Toulouse III -- Paul Sabatier and IRD have elucidated new molecular mechanisms involved in resistance to visceral leishmaniasis, a serious parasitic infection. They have shown that dectin-1 and mannose receptors participate in the protection against the parasite responsible for this infection, by triggering an inflammatory response, while the DC-SIGN receptor facilitates the penetration of the pathogen and its proliferation in macrophages[1]. This work, conducted on both mice and humans and published on 16 May 2013 in the journal Immunity, opens new perspectives for the prevention and treatment of this disease.

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