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Human Nature Sinks HIV Prevention Trial

A large-scale study of a biomedical intervention that potentially offers novel options for women to protect themselves from HIV infection has, to the surprise of many researchers, failed. But the results say more about the participants’ behavior than the effectiveness of the products being tested.

At the 20th Conference on Retroviruses and Opportunistic Infections held here from 3 to 6 March, infectious disease specialist Jeanne Marrazzo of the University of Washington, Seattle, reported the disappointing results of the study known as VOICE, which stands for Vaginal and Oral Interventions to Control the Epidemic.

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