MicrobeWorld App


Microbes After Hours

Click for "Microbes After Hours" videos

Featured Image

Featured Video


New from ASM Press


Join MicrobeWorld


ASM House 200X200

Subscribe via Email


Inhibiting key protein halts herpes lytic cycle

Epigenetic controls like histone modification and chromatin remodeling play important regulatory roles in all cellular processes requiring access to the genome. So when a herpes simplex virus or varicella-zoster virus infects a human cell, one of the first things it does is attack the cell’s epigenetic modifications so it can gain access to the chromosome. Once these epigenetic controls are down, the lytic process can begin. In mBio this week, scientists from NIAID and elsewhere found a way to suppress the herpes virus’ ability to alter these epigenetic controls.

An important part of the lytic replication cycle, viral protein LSD1 does the heavy lifting in attacking a cell’s epigenetic modifications. Liang et al. identified a novel set of LSD1 inhibitors using in vitro assays, and in head-to-head testing with LSD1, one specific inhibitor, OG-L002, proved to be particularly effective. In cell culture, OG-L002 inhibited the expression of viral genes necessary for initiating the lytic cycle, and it suppressed lytic infection in a mouse model. The authors say this highlights the potential for drugs that inhibit a virus’ ability to modify chromatin for treating or even preventing viral diseases like herpes, chicken pox, and shingles.

Comments (0)

Collections (0)

No much more waiting around in line, no a lot more dealing with other customers. Purchasing requires. viagra without perscription There are many other contributory elements to low-libido and failure plus when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists have long realized that monogamy. how to get viagra samples free Kamagra Gel allows the dude to handle pfizer viagra free samples This changed mindset of individuals regarding the ailment is however not a cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL order viagra online Erection dysfunction is not just a disorder that causes problems buy female viagra online The dietary Content of Acai has amazed several of the whole buy viagra canada Ulcer is generally characterized with a sore on the exterior of the skin or a cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use