Plant and animal cells have two genomes—in the nucleus and the mitochondria. A new study describes how a clash between the two makes fruit flies sick. Diseases from a mutation in one genome are complicated enough, but some illnesses arise from errant interactions between the DNA in the nucleus and in the mitochondria.
Scientists want to know more about how such genomic disconnects cause disease. In a step in that direction, scientists have traced one such incompatibility in fruit flies down to the level of individual nucleotide mutations and describe how the genetic double whammy makes the flies sick.
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