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TWiM 71 Letters

Zachary writes:

How long does it take to become a microbiologist?

Tim writes:

I'd never heard of magnetotactic bacteria before and thought perhaps you guys might find this interesting. Not sure if you've mentioned these on TWIM before, if so ignore this email.
Microbiology and Molecular Biology Reviews : MMBR 2013 Sep; 77 (3) : 497-526.
Ecology, diversity, and evolution of magnetotactic bacteria.
Christopher T Lefèvre, Dennis A Bazylinski
PMID: 24006473
Tim Zweber
Zweber Farms

Benjamin writes:

I listened to your podcast that discussed the primary literature article "A Burkholderia pseudomallei Toxin Inhibits Helicase Activity of Translation Factor eIF4A" that was published in Science. This article mentions that after the crystal structure for BPSL1549 was determined and they saw that it was a similar structure to CNF1-C, they created a mutated version that was not toxic, which they expected since the same happens in the mutated E. coli version of the protein.

Does this mean that if they find an agent to inhibit the protein that it would likely be able to work on both E. coli and B. pseudomallei toxins since they are similar? And is this a normal technique for treating bacterial infections since by targeting a protein rather than the bacterium it would leave the bacterium alive to make more of the protein toxin?

Thank you,


Ludwig writes:

Hello TWiM team,

Recently I saw an NPR article on a the disease SCID-X1, an X-chromosome linked immunodeficiency disorder where the body has no functioning immune system. I was wondering if I could hear your thoughts on how the microbiota would respond to this. I know prior research has shown that the immune system plays a role in shaping the community composition of the gut flora. How would the microbiota react to a complete absence of an immune system from birth?

Thank you and keep up the great work.

Will writes:

Hello TWiM team,
I’m a senior biology major who is bent on pursuing a career in microbial ecology. Last summer I discovered your podcast and I wish I had started listening earlier. You guys have been so great that you inspired me to start a biology talk show at my university’s radio station, titled ‘Disentangling the Bank’ for the iconic concluding paragraph of Charles Darwin’s On the Origin of Species. It’s a one hour program where two co-hosts and I summarize papers we found interesting that week and talk about the major results and implications. Because of your thorough preparation I’m always telling them to go to the primary source, much to their chagrin. We can’t go as in depth as your show, not only because we lack the knowledge which comes with being in the field for years, but also because this show is aired live to the public. This results in us heavily summarizing each paper. Nevertheless, we have a great time discussing the articles off-air in depth and it has become a sort of running joke that I always have a microbiology paper each week (never taken from your show though). Keep up the great work and thanks for the inspiration.



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