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Bacterial protein structure could aid development of new antibiotics

Bacterial cells have an added layer of protection, called the cell wall, that animal cells don’t. Assembling this tough armor entails multiple steps, some of which are targeted by antibiotics like penicillin and vancomycin.

Yet one step in the process has remained a mystery because the molecu... Read More

University of Miami Physicians Publish Case Study of First Locally Acquired Zika Infection

Following the recent Zika outbreak in Miami-Dade County, a multidisciplinary team of physicians with the University of Miami Health System and Miller School of Medicine published a case study January 11 in the New England Journal of Medicine, describing in detail the nation’s first locally trans... Read More

Cholera bacteria infect more effectively with a simple twist of shape

The bacteria that cause the life-threatening disease cholera may initiate infection by coordinating a wave of mass shapeshifting that allows them to more effectively penetrate the intestines of their unwitting victims, according to a study led by Princeton University.

The researchers discover... Read More

Genetically engineered mosquitoes resist dengue fever virus

After decades of research and countless control attempts, dengue fever--a mosquito-borne viral disease--continues to infect an estimated 390 million people around the world each year. Now, researchers have reported in PLOS Neglected Tropical Diseases that the mosquitos that carry dengue virus (D... Read More

Malaria elimination: Vaccines should be tested on larger groups of volunteers

To find an effective vaccine against malaria it is crucial to test candidate vaccines on larger groups of people than previously thought - according to a new study published in PLOS Computational Biology. The researchers from Erasmus MC Rotterdam and Radboud University Medical Center Nijmegen de... Read More

Malaria transmission may increase when more parasites are transferred via mosquito bite

Mosquitos carrying a greater number of malaria-causing parasites may be more likely to cause infection in the people they bite, according to a new study published in PLOS Pathogens.

More than 100 years have passed since scientists first discovered that infectious mosquitos inject malaria-caus... Read More

TWiM #143: E-scaffolds and receptor transfer

Vincent, Michael, and Michele explain the use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins.


Hosts: Vincent... Read More

TWiM 143 Letters

Peter writes:


Greetings TWiM Team


Thinking about the revised estimates for the number of bacterial and human cells in the body from 10:1 to about 1:1, I was wondering what the microbiome cell to self cells ratio is for different species.


I pr... Read More

Do the CDC's Suggested New Quarantine Rules Give Them Too Much Power?

When Kaci Hickox, a Doctors Without Borders nurse, returned to New Jersey from working with Ebola patients in West Africa in 2014, she was surprised by her reception. Instead of a quiet return to her home in Maine after four weeks on the front line of Ebola treatment, she was quarantined by the ... Read More

First Full Genome Analysis Solves the Mystery of How Zika Got So Dangerous

The mention of Zika can strike fear in the hearts of pregnant women. With infections increasing around the world, including in the US, researchers are fighting the clock to figure out how the virus can have such horrific effects in some people. Read More
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