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TNF receptors

What is Tumor necrosis factors (TNF) superfamily?

Tumor necrosis factors (TNF) superfamily composes of a group of cytokines and their receptors which can reduce cell death (apoptosis). This superfamily is composed of 19 ligands and 29 receptors in humans. TNFα and Lymphotoxin-alpha (LTα) is f... Read More

TGF beta superfamily

The transforming growth facor beta (TGF-β) superfamily is a large family of growth factors named after the first member TGF-β1. Members of TGF-β superfamily are similar in structure. TGF-β superfamily distributes in invertebrates as well as vertebrates species. They play role in dorso-ventral pa... Read More

interleukin receptors

IL superfamily, a member of larger group cytokines, is consisting of proteins called interleukins and interleukin receptors. IL superfamily members involve with variety of processes, including immunity, inflammation, and the formation of blood cells. IL superfamily members promote the growth of ... Read More

Chemokines

The chemokine family of proteins has broad, diverse functional repertoires. However, their structural variation is narrow. Chemokines are small (8-10 kDa), secreted single polypeptide chains 70-100 residues long. Across the family, the proteins have 20-95% amino acid sequence identity (including... Read More

Roquinimex inhibits dextran sodium sulfate-induced murine colitis

The majority of inflammatory bowel disease (IBD) consists of two related but clinically and histologically distinct conditions, ulcerative colitis and Crohn’s disease. Both conditions are characterized by chronically relapsing inflammation of the bowel of unknown etiology. Read More

Progress in The Development of New Drugs in Alzheimer’s Disease

Alzheimer’s disease (AD) is an age-related neurodegenerative disease that is characterized by a progressive loss of memory associated with other cognitive sphere deficits interfering with social and occupational functioning. Read More

Boston subway system covered in microbes, but they're not harmful

As part of its Microbiology of the Built Environment initiative, the Alfred P. Sloan Foundation started funding projects a few years ago that touched on the interaction of microbiology with architecture, buildings or, in the case of Curtis Huttenhower, PhD, an associate professor of computationa... Read More

Cross-respiration breathes life into a periodontal pathogen

Microbiome research has revealed that there are good guy and bad guy bacteria living together in complex communities on our skin, in our mouths, throughout our guts and pretty much everywhere in between. But what do you call a good guy bacterium that is aiding and abetting a disease culprit?

... Read More

UMMS scientists use CRISPR to discover Zika and dengue weaknesses

Scientists at the University of Massachusetts Medical School (UMMS) have performed the first CRISPR/Cas9 screen to discover human proteins that Zika virus needs for replication. This work, led by Abraham Brass, MD, PhD, assistant professor in microbiology & physiological systems, reveals new lea... Read More

How a cold gets into cells

Cold viruses cause us irritation by penetrating into our cells and transporting their RNA into the cytoplasma of the infected cells. This is the only way they can multiply. The details of how the transfer of the RNA from within the virus occurs are difficult to study. However, a new method has b... Read More

Tracking how bacteria threaten newborns

For years, researchers have struggled to get a handle on Group B streptococcus (GBS), in the hopes of improving neonatal outcomes. GBS are a bacteria commonly found in the vagina, rectum, and urinary tract of women. In healthy women, the bacteria are commensal, simply living without causing dise... Read More

Cross-respiration Between Oral Bacteria Leads to Worse Infections

Washington, D.C.—June 28, 2016—Researchers determined that two bacterial species commonly found in the human mouth and in abscesses, cooperate to make the pathogenic bacterium, Aggregatibacter actinomycetemcomitans, more infectious. Key to the cooperation is that the harmless partner provides th... Read More

Researchers Identify New Strategy for Decreasing Neonatal Mortality

Researchers have discovered how the bacteria Group B streptococcus (GBS) avoids detection by the immune system during pregnancy. The findings, reported in the journal mBio, could lead to the development of new drugs and strategies for treating GBS infection, which is a leading cause of neonatal ... Read More

Small RNAs regulate Bacteroides nutrient use

Just like you and me, bacteria have ‘favorite’ foods – though in the case of bacteria, 'favorite' translates to those which are energetically favorable or most accessible. Different bacteria have different preferences, based on their environments and the neighboring microbes that compete for or ... Read More

Anthrax capsule vaccine completely protects monkeys from lethal inhalational anthrax

Vaccination with the anthrax capsule--a naturally occurring component of the bacterium that causes the disease--completely protected monkeys from lethal anthrax infection, according to a study published online this week in the journal VACCINE. These results indicate that anthrax capsule is a hig... Read More

Mount Sinai researchers track HIV in real time as it infects and spreads in living tissue

By watching brightly glowing HIV-infected immune cells move within mice, researchers at the Icahn School of Medicine at Mount Sinai have shown how infected immune cells latch onto an uninfected sister cell to directly transmit newly minted viral particles. These interactions allow HIV to spread ... Read More

agar art

goggles of E.coli & Ent.aerogens .
in this pic goggles streak by using two organisms E.coli & Ent.aerogens on MacConkey's agar medium...MacConkey agar is selective as well as deferential plating medium....lactose fermenting bacteria produce pink or red color colony because of conversion of neu... Read More

BacterioFiles 257 - Phage Fibers Fight Phyllosphere Foes

This episode: Bacteria have repeatedly captured and used the tails of phages to fight each other!


(9 MB, 9.8 minutes)


Show notes: 
Journal Paper:

Hockett KL, Renner T, Baltrus DA. 2015. Read More

TWiV 395: The cancer thief

From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers. 


Hosts:  Read More

TWiP 112: A NOD to a tricky helminth

The TWiP trio solve the case of the Woman from Washington Heights, and reveal how helminth infection protects mice deficient in the Crohn's disease gene NOD2 from intestinal disease by inhibiting colonization with an inflammatory bacterial species.


Hosts:  Read More

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