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Taking out the defender

The in vivo interaction between a Pseudomonas aeruginosa biofilm, on a silicone implant, and the responding polymorphonuclear leukocytes.
Image: SEM imaging depicts the interaction at day 1 post insertion of the implant in the peritoneal cavity of a mouse. The leukocytes (yellow) are damaged wi... Read More

WHO says new coronavirus may be passed person to person

The World Health Organization says it appears likely that the novel coronavirus (NCoV) can be passed between people in close contact. This comes after the French health ministry confirmed a second man had contracted the virus in a possible case of human-to-human transmission. Two more people in ... Read More

Little Known Glomalin, a Key Protein in Soils

If you had heard of glomalin, you are a better person than I am. Until a couple of months ago I wasn’t aware of its existence, which is close to sinful: it happens to be a very abundant protein in the soil rhizosphere, playing a key role in the soil’s mechanical properties and as repository of s... Read More

Protein improves efficacy of tumor-killing enzyme

Researchers at NIAID have devised a method for delivering tumor cell-killing enzymes in a way that protects the enzyme until it can do its work inside the cell. In their study in mBio this week, researchers assembled microscopic protein packages that can deliver an enzyme called PEIII to the ins... Read More

Good Cholesterol: Part of Innate Immunity?

Trypanosome Lytic Factor (TLF) has emerged as a novel arm of innate immunity that is only present in humans and select non-human primates. TLF was originally discovered in human blood as a minor form of High-density lipoprotein (HDL), also known as a good cholesterol, that rapidly kills the Afri... Read More

Gene therapy: 'Heart-healing virus' trial starts

Patients in the UK have been enrolled into a trial to see if an engineered virus can be used to heal their damaged and struggling hearts. The trial will use a virus to introduce genetic material into heart muscle to reverse the organ's decline. The British Heart Foundation said the idea had "gre... Read More

Malaria: A Vector Infecting Both Apes and Humans

In 2010, a study revealed that the main agent of malaria in humans, called Plasmodium falciparum, arose from the gorilla. Today, the vector which transmitted the parasite from apes to humans has just been identified. A Franco-Gabonese research consortium has determined which species of anopheles... Read More

Saudi Arabia reports 4 new cases of dangerous virus

Health officials reported four more cases of a dangerous new virus in Saudi Arabia on Tuesday.

Three of the patients diagnosed as having the novel coronavirus, or nCoV, are still being treated, a statement on the Saudi Health Ministry website said. The fourth has been discharged from a hospit... Read More

Going viral on Science Sunday Hangout on Air

I joined Buddhini Samarasinghe and Scott Lewis on a Science Sunday Hangout on Air to talk about my career in virology: how I came to be interested in viruses, and what goes on in my laboratory. You can find hangouts and more at the ScienceSunday community.


{youtube}WpLH4gRk9gc{/youtub... Read More

Laser technology shaves time off bacteria turnaround

Scientists at a local laboratory say a new piece of technology there can identify bacteria a day earlier than traditional methods.

"If it's a blood infection or meningitis, getting that identification as fast as we can can mean the difference between life and death," said Karen Calvert, a mic... Read More

Could Adaptable Bacteria Cause Repeat UTIs?

Women suffering from recurring urinary tract infections may carry a particularly hearty strain of E. coli bacteria that flourishes in both the gut and the bladder, and can migrate back and forth despite repeated treatments, a small new study finds.

Doctors believe that urinary tract infection... Read More

Map of H7N9 fatalities and confirmed infections in China

Shanghai Daily has a web page set up that shows the geographic distribution of H7N9 infections and fatalities in China. There is also a news feed, information on symptoms and a photo gallery. Click "source" to view. Read More

Pictures Considered #4. Koch’s Development of Early InstaGram Positive Photography

Robert Koch is one of the key figures in early bacteriology, helping develop culture techniques (e.g. solid media), critical reasoning (e.g. Koch’s postulates), and disease etiology (e.g. cholera and tuberculosis). He also published the first photomicrographs of bacteria (Figure 1A) in his 1877 ... Read More

The Art of Microbial Alchemy

In 2001, Kashefi and collaborators published an article in Applied and Environmental Microbiology reporting the surprising finding that several iron-reducing microbes can use gold as an electron acceptor for their respiration. These microbial alchemists included both mesophilic and thermophilic ... Read More

Electron Beam Zaps Oysters to Kill Bacteria

Raw oysters, a delicacy for foodies and a purported hangover cure (it isn’t) aren’t always the safest thing to eat. Pathogens such as Vibrio vulnificus, norovirus and Hepatitis A sometimes lurk in oyster flesh. These little nasties can cause food poisoning and norovirus specifically has no treat... Read More

A Good Defense Is Worth Stealing

One widely-used tactic for defense against phage and other mobile genetic elements is to deploy a CRISPR-Cas system (click here and here) to recognize and chop them into pieces. Based on sequenced genomes, 60% of Bacteria and 90% of Archaea have the wherewithal to dispatch invaders this way. But... Read More

Pioneer bacteria lay down trails that draw new recruits

Bacteria may draw other bacteria to a site of infection by laying down trails of a “molecular glue” that lead free-swimming individuals to come together and organize into colonies.

In the study, researchers were looking at how a species of bacteria called Pseudomonas aeruginosa attach and mov... Read More

High-powered microscopic techniques give scientists detailed view of a critical component of cellular infrastructure

The cellular interior is criss-crossed by protein-based cables known as microtubules, each formed from 13 'protofilaments' composed of the protein tubulin. Microtubules are also associated with a host of other specialized proteins that help coordinate the transport of molecular cargoes and link ... Read More

Is There Evidence of a Supernova in the Fossils of Ancient Bacteria?

Back when the Time Lord and I were still engaged, we went shopping for wedding rings. He only had one criteria: he wanted his ring to be made of platinum or a similar material forged in a supernova. It’s not quite as exotic as it sounds: most heavy elements were formed in supernovae, via a proce... Read More

Lofted by hurricanes, bacteria live the high life

With cold temperatures, low humidity and high levels of ultraviolet (UV) radiation, conditions 10 kilometers above Earth’s surface may seem inhospitable. But next time you’re flying, consider this: The air outside your airplane window might be filled with an array of microscopic life that affect... Read More

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