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Urease: an anti-microbial target in bacteria and fungi

Urea is a small molecule formed as proteins are broken down. It’s excreted in urine, but isn’t particularly toxic at low levels so it’s found in cells throughout the body. The molecular structure of urea is below, and as it contains nitrogen (N) several pathogens have adapted to use it as a nitr... Read More

Metallic Sheen in m Endo Agar

I am Sagar Aryal, Global Outreach Member of ASM, currently studying M.Sc. Medical Microbiology at St. Xavier's College, Kathmandu, Nepal.
This is the picture of presence of metallic sheen in m Endo Agar while detecting the coliforms in different water sample of kathmandu valley by membrane fil... Read More

Protein's "hands" enable bacteria to establish infection, research finds

When it comes to infecting humans and animals, bacteria need a helping hand.

Kansas State University biochemists have found the helping hand: groups of tiny protein loops on the surface of cells. These loops are similar to the fingers of a hand, and by observing seven individual loops on the ... Read More

Host genetics can contribute to lung damage in severe tuberculosis

A third of the global population is infected with the bacterial pathogen that causes tuberculosis. Most carriers control the infection and are asymptomatic, but severe forms of the disease kill over a million people every year. A new article now identifies a factor made by the host that exacerba... Read More

U.K. Supermarket To Run On Electricity Made From Its Own Rotting Food

The joys of anaerobic digestion

One U.K. grocery store plans to power itself using biogas harvested from its own unsold, rotting produce. Yum.

A Sainsbury's store in Cannock in central England is getting access to anaerobic digesters. The store plans to use electricity solely from the dige... Read More

Ocean microbes display a hidden talent: releasing countless tiny lipid-filled sacs

In the search for a renewable energy source, systems using algae look like a good bet. Algae can grow quickly and in high concentrations in areas unsuitable for agriculture; and as they grow, they accumulate large quantities of lipids, carbon-containing molecules that can be extracted and conver... Read More

Report on Viruses Looks Beyond Disease

Recently, the American Academy of Microbiology released a new report, Viruses Throughout Life & Time: Friends, Foes, Change Agents that delves into the origin of viruses, the overlooked biological and microbial ecological role of viruses, and how these live forms have contributed to evolution. T... Read More

Oregon geologist says Curiosity's images show Earth-like soils on Mars

Soil deep in a crater dating to some 3.7 billion years ago contains evidence that Mars was once much warmer and wetter, says University of Oregon geologist Gregory Retallack, based on images and data captured by the rover Curiosity.

NASA rovers have shown Martian landscapes littered with loos... Read More

Malaria control: The great mosquito hunt

The armed guards at Mali's Bamako Senou International Airport had never seen a German shepherd before. The only dogs they were familiar with were the small, scrappy mixed breeds that are common in West Africa. So when Dana, a wolf-like purebred from California, stepped off a plane and into the a... Read More

Methyl Red/Vogoes-Proskauer (MR-VP)

Methyl Red/Vogoes-Proskauer (MR-VP)
One medium used for two separate but related tests, identifying butanediol (VP) or acidic fermentation products (MR) as part of the IMViC test used in the identification of Enterobacteriaceae.

•Methyl Red (MR): detects the ability of an organism to produc... Read More

HIV detected in “cured” Mississippi Baby, Creating Huge AIDS Therapy Setback

Disappointed federal officials today announced that the “Mississippi baby,” thought to have been cured of HIV with an aggressive treatment regimen, now has detectable levels of virus. The sad news, upsetting for the family of the 46-month-old girl, also dashed the hopes of clinicians who believe... Read More

Study examines therapeutic bacteria’s ability to prevent obesity

A probiotic that prevents obesity could be on the horizon.

Bacteria that produce a therapeutic compound in the gut inhibit weight gain, insulin resistance and other adverse effects of a high-fat diet in mice, Vanderbilt University investigators have discovered.

“Of course it’s hard to spec... Read More

Animating the Inanimate

Concrete is the most widely used building material in the world, with untold amounts being produced yearly. It has always been regarded as a strong, solid, impenetrable, almost indestructible material yet it can make cracks that are vulnerable to penetration by water. As the result, structures ... Read More

Fluorescence staining of direct sputum smear showing numerous bacilli of Mycobacteria.

Fluorescence staining of a direct sputum smear from a patient of chronic bronchitis showing numerous bacilli of Mycobacterium tuberculosis. Read More

TWiM 83 Letters

Matt writes:


Hello TWiM team,

It was great seeing some of you at ASM last week in Boston either in passing between sessions or at the live TWiV episode. I have a few questions about the ASM meeting:
What was something that you all took away from ASM th... Read More

Getting a Knit Bacteriophage From a Former Student!

A former student dropped by my lab this morning, and brought me a gift: a knit bacteriophage! Many times, as educators, we hear what we haven't done well, or could do better. Sometimes, like today, we get a priceless "thank you" from a former student. Read More

Pictures Considered #18. Pictures of Shigella by Shiga

The journal Zentralblatt für Bakteriologie, Parasitenkunde u. Infektionskrankheiten was one of the leading publication in the early days of Microbiology. Many of the great discoveries of microbial pathogens were published therein. An example is the 1898 Japanese microbiologist Kiyoshi Shiga acco... Read More

Drug Combo Can Sure Hepatitis C in Patients With HIV

A new combination drug therapy cures chronic hepatitis C in most patients also infected with HIV—and without the side effects of current treatments.

The advance is important, researchers say, because about a third of HIV patients in the United States also have hepatitis C. There are an estima... Read More

More than glitter: Scientists explain how gold nanoparticles easily penetrate cells, making them useful for delivering drugs

A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells.

A new study from MIT materials scientists reveals that these nanoparticles enter cells by taking advantage of a route normally used in vesicle-... Read More

Calcium makes for an environmentally friendly pickle

George Washington had a collection of 476 kinds of pickles. To prevent scurvy, Christopher Columbus stocked pickles on the Niña, Pinta, and Santa Maria. Julius Caesar, believing pickles to be invigorating, added them to the Roman legions' diet. In 5000 BCE, the Babylonians were known for picklin... Read More
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