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CRISPR screening identifies potential HIV treatment targets

Investigators from the Ragon Institute of MGH, MIT and Harvard and the Broad Institute of MIT and Harvard have used the revolutionary new gene-editing technology CRISPR-Cas9 to identify three promising new targets for treatment of HIV infection. In their report receiving advance online publicati... Read More

Threading the RSV vaccine needle

Crafting a vaccine against RSV (respiratory syncytial virus) has been a minefield for 50 years, but scientists believe they have found the right balance.

Researchers at Emory University School of Medicine and Children's Healthcare of Atlanta report that they have engineered a version of RSV t... Read More

DNA binding by C. crescentus VapBC1 (video)

The video shows the structural changes in the Caulobacter crescent VapBC1 protein complex during DNA binding, including how the antitoxin “tails” containing the protein palindromic sequences switch positions.

Link to the research article in Nucleic Acids Research http://nar.oxfordjournals.org... Read More

Researchers reveal the secret code language of bacteria

Antibiotic resistance in pathogenic bacteria is a growing global challenge. Danish researchers have now discovered that bacteria use a code language to avoid being controlled. Understanding this code language will be paramount to developing new antibiotics in the future.

Pathogenic bacteria –... Read More

Reconstructing a lichen's molecular architecture

Chemist Pieter Dorrestein’s laboratory group has been developing mass spectrometry methods to look at what molecules are produced by microbes interacting in a petri dish. But recently, the group jumped out of the dish and into the dirt—to analyze a soil-dwelling lichen and discover how the molec... Read More

First chikungunya vaccine from virus that does not affect people

Researchers from The University of Texas Medical Branch at Galveston have developed the first vaccine for chikungunya fever made from an insect-specific virus that doesn’t have any effect on people, making the vaccine safe and effective. The newly developed vaccine quickly produces a strong immu... Read More

UTMB develops an oral vaccine against Salmonella

Researchers from The University of Texas Medical Branch at Galveston have developed a vaccine against salmonella poisoning designed to be taken by mouth. The findings are detailed in an article published in Frontiers in Cellular and Infection Microbiology.

In earlier studies, the UTMB researc... Read More

El Niño fueled Zika outbreak, new study suggests

Scientists at the University of Liverpool have shown that a change in weather patterns, brought on by the 'Godzilla' El Niño of 2015, fuelled the Zika outbreak in South America.

The findings were revealed using a new epidemiological model that looked at how climate affects the spread of Zika ... Read More

Ancient Chinese malaria remedy fights TB

A centuries-old herbal medicine, discovered by Chinese scientists and used to effectively treat malaria, has been found to potentially aid in the treatment of tuberculosis and may slow the evolution of drug resistance.

In a promising study led by Robert Abramovitch, a Michigan State Universit... Read More

Sunlight offers surprise benefit -- it energizes infection fighting T cells

Sunlight allows us to make vitamin D, credited with healthier living, but a surprise research finding could reveal another powerful benefit of getting some sun.

Georgetown University Medical Center researchers have found that sunlight, through a mechanism separate than vitamin D production, e... Read More

Toward better understanding of fecal microbiota transplants

In recent years, researchers have learned that gut microbiota play a role in a number of human diseases, including Clostridium difficile infection, irritable bowel syndrome, Parkinson’s disease, and autism spectrum disorder. The revelations have scientists hopeful that fecal microbiota transplan... Read More

Zika-linked birth defects more extensive than previously thought, UCLA-led research finds

New UCLA-led research finds that Zika-linked abnormalities that occur in human fetuses are more extensive — and severe — than previously thought, with 46 percent of 125 pregnancies among Zika-infected women resulting in birth defects in newborns or ending in fetal death.

The study, published ... Read More

Tuberculosis virulence factor identified, may be target for new drug

Scientists have discovered the mechanism that hijacks the immune system's response to tuberculosis, revealing an important new drug target for the disease that kills more than 1 million people each year.

Herman Sintim, Purdue University's Drug Discovery Professor of Chemistry, collaborated wi... Read More

Listeria infections stable but frequently reported among the elderly

European experts have noted an increasing trend of listeriosis since 2008, but they highlight that the number of affected people stabilised from 2014 to 2015. Infections were mostly reported in people over 64 years of age. These are some of the findings of the latest annual report by EFSA and EC... Read More

Important element of immune defense against fungal infections discovered

Fungal infections are a serious health risk. They can be harmful especially to patients whose immune system is compromised through illness or chemotherapy. A team working at the Technical University of Munich (TUM) has discovered an important mechanism in the body's defenses against fungi. The d... Read More

A suggested bundle to reduce carbapenem use

Too many carbapenems used in your hospital? Worried about carbapenem resistance? There is no magic bullet... Here is a suggested bundle to consider utilising to reduce carbapenem use. As with all bundles, it may be difficult to show a measurable effect with each individual component, but when al... Read More

TWiV 420: Orthogonal vectors

The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines.


Hosts: Vincent Racaniello Read More

The Natural History of Cheese Mites

They are right on the border of what is visible and invisible. If you look really close at a piece of aged cheese, it’s possible to see them, barely. The more “artisanal” the cheese, the better the chance that they are there: living within tiny burrows on the rind proportionally the size of gian... Read More

SUBMIT MICROBE ABSTRACTS NOW: ONE IN FIVE ACCEPTED WILL BE ORAL PRESENTATION

The call for abstracts is now open for Microbe 2017, the premier microbiology conference hosted by the American Society for Microbiology. This is your opportunity to submit your important research in the microbial sciences to the largest scientific audience, with a 50% higher chance of presentin... Read More

TWiM #141: Nutritional immunity and polymicrobial infections

Jennifer joins Vincent, Elio, and Michael to talk about the work of her laboratory on how a respiratory virus enhances bacterial growth by dysregulating nutritional immunity.


Hosts: Vincent Racaniello, ... Read More

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