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Protein ID'd as possible universal therapeutic target for many infections, including Ebola

A protein called GRP78 could be a universal therapeutic target for treating human diseases like brain cancer, Ebola, Influenza, Hepatitis and superbug bacteria such as MRSE and MRSA, according to a Virginia Commonwealth University-led pre-clinical study published this month in the Journal of Cel... Read More

Immune upgrade gives 'HIV shielding'

Doctors have used gene therapy to upgrade the immune system of 12 patients with HIV to help shield them from the virus's onslaught. It raises the prospect of patients no longer needing to take daily medication to control their infection. The patients' white blood cells were taken out of the body... Read More

Commonly used pain relievers have added benefit of fighting bacterial infection

Some commonly used drugs that combat aches and pains, fever, and inflammation are also thought to have the ability to kill bacteria. New research reveals that these drugs, better known as nonsteroidal anti-inflammatory drugs, act on bacteria in a way that is fundamentally different from current ... Read More

Artificial Spleen Cleans Ebola from Blood

Researchers have developed a high-tech method to rid the body of infections — even those caused by unknown pathogens. A device inspired by the spleen can quickly clean blood of everything from Escherichia coli to Ebola, researchers report on September 14 in Nature Medicine.

Blood infections c... Read More

Micrococcus luteus line inoculation

Line inoculation of Micrococcus luteus on a TSA slant showing Filiform, uniform growth, along the margin. Culture was grown for 3 days at 37 degrees, M. luteus usually takes 3+ days for good growth. Read More

Hot-spring bacteria reveal ability to use far-red light for photosynthesis

This video contains images of LaDuke hot spring in Gardiner, Montana, along the Yellowstone River, near Yellowstone National Park. The images show the rich mat community of chlorophototrophic bacteria that grow along the hot spring's effluent channel. The dark-green-colored organisms are mainly ... Read More

How E. coli passes safely through stomach acid

In some parts of the world, many small children become infected with severe diarrhea which often proves fatal. The condition is usually caused by strains of Escherichia coli (commonly known as E. coli) bacteria, and bacteria of the genus Yersinia. These bacteria attach themselves to the wall of ... Read More

Getting a Knit Bacteriophage From a Former Student!

A former student dropped by my lab this morning, and brought me a gift: a knit bacteriophage! Many times, as educators, we hear what we haven't done well, or could do better. Sometimes, like today, we get a priceless "thank you" from a former student. Read More

ICAAC 2014 - New Antimicrobial Strategy Silences NDM-1 Resistance Gene in Pathogens

Researchers have created a synthetic DNA analog that can bind to and silence the gene responsible for NDM-1, a severe form of antibiotic resistance that can make ... Read More

Methyl Red/Vogoes-Proskauer (MR-VP)

Methyl Red/Vogoes-Proskauer (MR-VP)
One medium used for two separate but related tests, identifying butanediol (VP) or acidic fermentation products (MR) as part of the IMViC test used in the identification of Enterobacteriaceae.

•Methyl Red (MR): detects the ability of an organism to produc... Read More

Giant virus revived from deep freeze in Siberian tundra

A 30,000-year-old giant virus has been revived from the frozen Siberian tundra, sparking concern that increased mining and oil drilling in rapidly warming northern latitudes could disturb dormant microbial life that could one day prove harmful to man.

The latest find, described online Monday ... Read More

The day they discovered the AIDS virus

A historical look back at the discovery of the AIDS virus. Margaret Heckler, president Reagan's Health and Human Services Secretary made the announcement to the world. “First, the probable cause of AIDS has been found: a variant of a known human cancer virus. Second, not only has the agent been ... Read More

TWiM 85 Letters

Tom writes:


Hi TWIM, TWIV and TWIP Argonauts,


Your three wonderful podcasts are the nutrient media for growing my scientific knowledge. I have been downloading them from ITunes for a couple of years, and although as a mere amateur I sometimes struggle to keep ... Read More

Sweet Valentine

Four intracellular Toxoplasma gondii parasites are shown undergoing cellular division by an internal budding process known as endodyogeny. Staining with a T. gondii surface antigen provided heart-shaped images (shot on Valentine’s Day). The definitive host of these parasites is the cat, but they... Read More

My No-Soap, No-Shampoo, Bacteria-Rich Hygiene Experiment

For most of my life, if I’ve thought at all about the bacteria living on my skin, it has been while trying to scrub them away. But recently I spent four weeks rubbing them in. I was Subject 26 in testing a living bacterial skin tonic, developed by AOBiome, a biotech start-up in Cambridge, Mass. ... Read More

"Microbe-Powered Jobs: How Microbiologists Can Help Build the Bioeconomy" Infographic

The American Academy of Microbiology has just released a new report, "Microbe-Powered Jobs: How Microbiologists Can Help Build the Bioeconomy," and along with it, an infographic, that summarizes the main points of the report. The full report can be found here: http://bit.ly/1lk346I, and a link t... Read More

TWiV 314: Einstein goes viral

Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.


Host:  Read More

Why are bacteria all the same size

Just when we think we know everything, a story comes along to remind us that there is something fundamental--and seemingly elementary--that we still haven't figured out. “Why are we the size we are? Why are our organs the size they are? Why are the cells in those organs a stereotypical size? Wha... Read More

Streptococcus pyogenes Gram Stain

Gram stain done on S. pyogenes showing the characteristic long G+ streptococcus chains. Culture grown on blood agar for 48 hrs at 37 degree’s C. Read More

Positive clinical results indicate vaccine candidate is highly efficacious against bacterial diarrhea

New results from a safety and immunogenicity study, which included a challenge phase to test efficacy, indicate that a live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine candidate, given in combination with a novel adjuvant, provided significant protection against disease. This repr... Read More
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