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A WORD on the constraints of influenza virus evolution

Evolution proceeds by selection of mutants that arise by error-prone duplication of nucleic acid genomes. It is believed that mutations that are selected in a gene are dependent on those that have preceded them, an effect known as epistasis. Analysis of a sequence of changes in the influenza vir... Read More

High Dose Therapy for Influenza Drug - ICAAC 2013

Critically ill patients with the pandemic H1N1 influenza who received triple the standard dose of the influenza drug oseltamivir were 7 times more likely to completely clear the virus from their system in 5 days than those who received the standard dose. This discussion addresses the healthcare... Read More

GM rice delivers antibodies against deadly rotavirus

Researchers have added an antibody to fight rotavirus into the rice genome. A strain of rice genetically engineered to protect against diarrhoeal disease could offer a cost-effective way to protect children in developing countries, according a study published in the Journal of Clinical Investiga... Read More

Bespoke microbiome therapy to manage plant diseases

In this paper we describe the perspective of following the achievements in medicine, where gut microbiome transplants are proving to be a powerful method to overcome several gastrointestinal disorders and many other physiological problems, to possible solve diseases in plants. There is strong si... Read More

To combat the overuse of antibacterials, stop using the absolutely terrible word, "antibiotic"

There are many reasons why bacteria evolve resistance to antibacterials, but one of the preventable reasons is the over-prescription of antibacterials to patients who don't have bacterial infections. But how to get people to stop asking for antibacterials? My suggestion is to stop using the wor... Read More

TWiP 65 letters

 


Perry writes:


Greetings Vincent and Dick,


Hooray for finally mentioning G. pulchrum in episode 62, my most favorite parasite and one worthy of further discussion. As a diagnostic veterinary pathologist, I encounter this spirurid in approximately... Read More

MAP OF THE DAY: States With 'Nightmare Bacteria' 2001 Vs. 2013

Each year, 2 million people get an infection that is resistant to antibiotics, the CDC has reported. Twenty-three thousand of them die as a result of the infection, and many more die from related complications.

Carbapenem-resistant Enterobacteriaceae (CRE) are just one variety of antibiotic-r... Read More

The protective milk shot – How mother’s milk protects piglets from parasite infections

Coccidiosis is a serious disease in new-born piglets. Caused by the parasite Cystoisospora suis, it exclusively infects pigs and often causes severe diarrhoea in suckling piglets. Parasitologists at the Vetmeduni Vienna have developed a new strategy for protecting the piglets: They infected sows... Read More

Hijacking bacteria's natural defences to trap and reveal pathogens

Bad bacteria could soon have no place left to hide, thanks to new materials that turn the cell’s own defences against them.

Scientists at The University of Nottingham and GSK Consumer Healthcare have developed a technique that could locate the potential source of an infection by hijacking the... Read More

Bird flu researchers want to create deadly virus in lab

Researchers said Wednesday they want to create a lab version of a deadly emerging bird flu in order to study a strain that might be more infectious to people. Responding to past concerns about such research, the U.S. government said it will require extra safety measures.

The H7N9 bird flu vir... Read More

Frozen bacteria repair their DNA at -15ºC

Bacteria encased in ice can be resuscitated after thousands, perhaps even millions of years. How these hardy bugs manage to survive deep freeze is something of a mystery. If nothing else, the low levels of radiation hitting Earth’s surface should cause any ice-bound bacterium’s DNA to break apa... Read More

Yersinia pestis bacteria

Scanning electron micrograph of Yersinia pestis, which causes bubonic plague, on proventricular spines of a Xenopsylla cheopis flea. Credit: National Institutes of Health/Department of Health and Human Services (NIAID) Read More

Pig-killing PEDv virus moves into Canada

Canada has discovered its first two cases of the Porcine Epidemic Diarrhea virus (PEDv), which has already killed more than 1 million pigs in the United States, government and industry officials said on Thursday.

The Ontario government is investigating a hog farm in the province's Middlesex C... Read More

The Science Behind Honey’s Eternal Shelf Life

Modern archeologists, excavating ancient Egyptian tombs, have often found something unexpected amongst the tombs’ artifacts: pots of honey, thousands of years old, and yet still preserved. Through millennia, the archeologists discover, the food remains unspoiled, an unmistakable testament to the... Read More

Paint a virus to death

An Auckland scientist has invented molecules that can attach themselves to any surface in a few minutes and modify every type of cell or virus. The potential for the technology is huge - from attacking cancer cells to protecting newborn babies. Read More

Mycobacterium smegmatis using transmitted light

Isolated colony of Mycobacterium smegmatis grown on TSA for 96 hrs at 37 degrees C. Margin is lobate with an irregular-rhizoid form. Image taken using transmitted light. Read More

IDRI: Using Microbiology to Defeat TB

Dr. Tanya Parish and her TB Disco Team at IDRI use microbiology to develop new drugs for TB and improve the health of the world! Read More

Japanese superfood prevents flu infection

Scientists have discovered that bacteria found in a traditional Japanese pickle can prevent flu. Could this be the next superfood?

The research, which assesses the immune-boosting powers of Lactobacillus brevis from Suguki – a pickled turnip, popular in Japan – in mice that have been exposed ... Read More

Ocean microbes display remarkable genetic diversity in each drop of seawater

The smallest, most abundant marine microbe, Prochlorococcus, is a photosynthetic bacteria species essential to the marine ecosystem. An estimated billion billion billion of the single-cell creatures live in the oceans, forming the base of the marine food chain and occupying a range of ecological... Read More

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