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TWiM 38 Letters

Jim writes:

As usual I loved TWiM #37. Jo Handlesman adds a lot imho.

I think Michael Schmidt meant "dump data" instead "data dump."  Apologizes to Alan Dove.
<... Read More

NEJM: The Burden of Disease and the Changing Task of Medicine

At first glance, the inaugural 1812 issue of the New England Journal of Medicine and Surgery, and the Collateral Branches of Science seems reassuringly familiar: a review of angina pectoris, articles on infant diarrhea and burns. The apparent similarity to today's Journal, however, obscures a fu... Read More

A viral mashup in snakes

If you know anything about snakes you might be familiar with snake inclusion body disease, or IBD. This transmissible and fatal disease affects snakes of a variety of species but has been best studied in boas. The name comes from the presence of large masses (inclusions) in the cytoplasm of cell... Read More

Prosthogonimus macrorchis

Prosthogonimus macrorchis, a flatworm poultry parasite.

A digenetic trematode (family Prosthogonimidae) located in the oviduct and bursa fabricii of poultry in North America, particularly common in states bordering the Great Lakes. (http://www.medilexicon.com) Credit: Mr. Spike Walker

2010... Read More

Exploring HIV - Illustration by David S. Goodsell

If we can visualize a protein's shape, we can learn much more about how it functions and how we might block its activity. This was the guiding principle behind an NIH initiative launched 25 years ago to spur the discovery of HIV-related protein structures. Structures produced through the program... Read More

Common bacteria may cause colic

A bacteria that is known to be associated with more than 80% of gastric and doudenal ulcers, may be associated with infant colic. The bacteria, Helicobacter Pylori (H.pylori), is found in the lining of the of the stomach wall.

Dr. Abdelrazak Mansour Ali from Al-Azhar University in Cairo, Egyp... Read More

TWiV 192: Viral tertulia



Hosts: Vincent Racaniello, Alan Dove, and  Read More

Human Microbiome Journal Club: The Pros of Probiotics

We’ve all heard the claims of probiotic yogurts and their benefits for human health, but aside from improving our belly dancing skills, what exactly are probiotic bacteria doing?

An elegant study from the Jeffrey Gordon lab explored the effects of consuming fermented milk products (FMPs) cont... Read More

Fermented Fashion via @wabibitotweets @phylogenomics

The Micro'be' project by contemporary textile artist and lecturer Donna Franklin, and scientist Gary Cass, explores fashion and technology's newest frontier: garments made from the bacterial fermentation of wine and beer.

The project's eureka moment came about through a vat of Australian red... Read More

Moffitt Cancer Center Researchers Discover How Cancer Cells “Hijack” a Mechanism to Grow

Researchers at Moffitt Cancer Center and colleagues at the University of South Florida have discovered a mechanism that explains how some cancer cells “hijack” a biological process to potentially activate cell growth and the survival of cancer gene expression.

Their study appeared in a recen... Read More

Seven Wonders of the Microbe World (combined)

From the Open University, a neat video highlighting seven amazing things microbes do. Read More

New study maps hotspots of human-animal infectious diseases and emerging disease outbreaks

A new global study mapping human-animal diseases like tuberculosis (TB) and Rift Valley fever finds that an "unlucky" 13 zoonoses are responsible for 2.4 billion cases of human illness and 2.2 million deaths per year. The vast majority occur in low- and middle-income countries.

The report, wh... Read More

TWiV 194: Five postdocs in North America



Hosts: Vincent Racaniello, Matthew Daugherty, Jondavid deJong, Hel... Read More

Study upholds immune system’s role in autism

Changes in an overactive immune system can contribute to autism-like behaviors in mice, new research shows.

Scientists at the California Institute of Technology (Caltech) pioneered the study of the link between irregularities in the immune system and neurodevelopmental disorders such as auti... Read More

Titan's tides reveal hidden ocean that could host life

Alien hunters take note: a global water ocean potentially bigger than all those on Earth combined, is sloshing beneath Titan's icy crust.

Combined with the cocktail of organic chemicals already known to exist on Titan, abundant water could make the moon prime real estate for life – though mor... Read More

EP67 Protein May Prevent Flu By Boosting Immune System, Mouse Study Suggests

Scientists may have pinpointed a potential way to prevent the flu by identifying a protein that amps up the immune system, according to a new animal study.

The synthetic protein, called EP67, is able to trigger an immune response to the "threat" of the flu virus within a couple of hours in mi... Read More

Is it Ebolavirus or Ebola virus?

When I drafted my article for TakePart (Don’t Panic – Ebola Isn’t Heading For You), I used the term ‘ebolavirus’ throughout, but the editors changed every instance to ‘Ebola virus’. Understanding which term is correct is far more complicated than you might imagine. Read More

TWiV 189: Five postdocs in Glasgow



Hosts: Vincent Racaniello, Vanessa Cowton, Mary Holton, Mark Robinson, Swetha Vijayakrishnan, and Gavin Wilkie


Vincent returns to t... Read More

The Extra Pounds You Can't Afford to Lose: An Interview With Microbiologist Margaret McFall-Ngai

Recent revelations about our microscopic partners and tenants are numerically startling, if not downright existential. Try these for starters: Most of the cells within your body are not human cells, and you are literally teeming with pounds of busy microbes, working to earn their keep while you ... Read More

Built-in dengue virus killer found in humans

Scientists may have hit gold in their fight against dengue. They have located a human antibody that can neutralise and kill its virus within two hours.

Significantly, they have also identified a way to reproduce this antibody in large quantities, potentially opening the door to a cure for den... Read More

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