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A system‐level model for the microbial regulatory genome

Microbes can tailor transcriptional responses to diverse environmental challenges despite having streamlined genomes and a limited number of regulators. We present data‐driven models that capture the dynamic interplay of the environment and genome‐encoded regulatory programs of two types of prok... Read More

TWiV 294: Smallpox and anthrax and flu, oh my!

The TWiV team reviews the discovery of old vials of smallpox virus at NIH, anthrax and influenza mishaps at CDC, the baby who was not cured of HIV, Cambridge Working Group, and sacking of NSABB members.


Hosts:  Read More

TWiP 75: Parasite wonders with Bobbi Pritt

Bobbi Pritt joins Vincent and Dickson to talk about directing a clinical parasitology laboratory and her weekly case reports at Creepy Dreadful Wonderful Parasites.


Hosts: Vincent Racaniello and  Read More

TWiM #83: Illuminating tuberculosis and cryptococcosis

Hosts: Vincent RacanielloMichael Schmidt, ... Read More

When the Microbe Hits the Metal

Some heavy metals share a long history with microbes. Many of the metabolic processes that sustain life are believed to have originated from spontaneous reactions involving metals present in the early Earth. Our microbial ancestors figured out quickly how to use those metal catalysts to generate... Read More

Molecular Computer Detects Ebola and Marburg Viruses

Material from deadly pathogens triggers alerts directly, and could speed detection. Early detection is key to slowing outbreaks of Ebola, such as the one currently spreading across west Africa that is estimated to have infected almost 1000 people, according to the latest World Health Organizatio... Read More

TWiP 75 letters


David writes (re lice and iron):


All I remember that I know is that one time I let my cat endure a heavy flea infestation for an unconscionably long time. I redeemed myself, if at all, by the knowledge that I slept with her a lot, and so endured a share myself (b... Read More

Methyl Red/Vogoes-Proskauer (MR-VP)

Methyl Red/Vogoes-Proskauer (MR-VP)
One medium used for two separate but related tests, identifying butanediol (VP) or acidic fermentation products (MR) as part of the IMViC test used in the identification of Enterobacteriaceae.

•Methyl Red (MR): detects the ability of an organism to produc... Read More

Urease: an anti-microbial target in bacteria and fungi

Urea is a small molecule formed as proteins are broken down. It’s excreted in urine, but isn’t particularly toxic at low levels so it’s found in cells throughout the body. The molecular structure of urea is below, and as it contains nitrogen (N) several pathogens have adapted to use it as a nitr... Read More

Researchers Find New Way to Kick Out HIV From Infected Cells

The technique addresses the problem of hidden reservoirs of HIV in the body, and could herald a new way of battling the viral infection.

Once HIV invades the body, it doesn’t want to leave. Every strategy that scientists have developed or are developing so far to fight the virus – from powerf... Read More

Report on Viruses Looks Beyond Disease

Recently, the American Academy of Microbiology released a new report, Viruses Throughout Life & Time: Friends, Foes, Change Agents that delves into the origin of viruses, the overlooked biological and microbial ecological role of viruses, and how these live forms have contributed to evolution. T... Read More

Land of the bacteria-eaters

For hospital workers an outbreak of harmful bacteria in the wards is a nightmare, but what gives bacteria nightmares?

Perhaps the prospect of being eaten alive by a kind of viral parasite called a bacteriophage (bacteria eater): unlike antibiotics, which some bacteria have evolved a resistanc... Read More

U.K. Supermarket To Run On Electricity Made From Its Own Rotting Food

The joys of anaerobic digestion

One U.K. grocery store plans to power itself using biogas harvested from its own unsold, rotting produce. Yum.

A Sainsbury's store in Cannock in central England is getting access to anaerobic digesters. The store plans to use electricity solely from the dige... Read More

BacterioFiles 175 - Bacteria Build Better Biofilms

This episode: Engineered bacteria can be made to produce many different useful kinds of biofilm!


(10.5 MB, 11.5 minutes)


Show notes: 
News item 1/ Read More

Study examines therapeutic bacteria’s ability to prevent obesity

A probiotic that prevents obesity could be on the horizon.

Bacteria that produce a therapeutic compound in the gut inhibit weight gain, insulin resistance and other adverse effects of a high-fat diet in mice, Vanderbilt University investigators have discovered.

“Of course it’s hard to spec... Read More

More than glitter: Scientists explain how gold nanoparticles easily penetrate cells, making them useful for delivering drugs

A special class of tiny gold particles can easily slip through cell membranes, making them good candidates to deliver drugs directly to target cells.

A new study from MIT materials scientists reveals that these nanoparticles enter cells by taking advantage of a route normally used in vesicle-... Read More

TWiM 83 Letters

Matt writes:


Hello TWiM team,

It was great seeing some of you at ASM last week in Boston either in passing between sessions or at the live TWiV episode. I have a few questions about the ASM meeting:
What was something that you all took away from ASM th... Read More

Drug Combo Can Sure Hepatitis C in Patients With HIV

A new combination drug therapy cures chronic hepatitis C in most patients also infected with HIV—and without the side effects of current treatments.

The advance is important, researchers say, because about a third of HIV patients in the United States also have hepatitis C. There are an estima... Read More

HIV, malaria, and tuberculosis: Success of the Millennium shown in most comprehensive study to date

Accelerated progress against the global burden of HIV, malaria, and tuberculosis (TB) has been made since 2000 when governments worldwide adopted Millennium Development Goal 6 to combat HIV/AIDS, malaria, and TB. New estimates from a major new analysis show that worldwide, the number of people l... Read More

Ancient genetic material from caries bacterium obtained for the first time

A UAB research concludes that the Streptococcus mutans, one of the principal bacteria causing dental caries, has increased the changes in its genetic material over time, possibly coinciding with dietary changes linked to the expansion of humanity.

Click "source" to read more. Read More
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