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Typhoid toxin increases host survival and promotes asymptomatic infection

Genotoxins damage the genetic material in cells and can cause mutations and cancer. Some bacteria code for and produce genotoxins. A study published on April 7th in PLOS Pathogens reports the surprising finding that one of them, typhoid toxin, actually increases survival of the infected host and... Read More

MMP #17: How bacteria can change graphene to propel rotors.

Host: Jeff Fox with special guests, Julia Yeomans and Vikas Berry.


Julia Yeomans of Oxford University in the United Kingdom and chemical engineer
Vikas Berry of the University of Illinois, Chicago, talk with Jeff Fox about their separate, but in some ways similar, research effor... Read More

Biological factors predict which viruses will cause human epidemics

The identification of biological factors that predict which viruses are most likely to spread among humans could help prevent and contain outbreaks, a study in today's Proceedings of the National Academy of Sciences reports. Read More

Experimental dengue vaccine protects all recipients in virus challenge study

A clinical trial in which volunteers were infected with dengue virus six months after receiving either an experimental dengue vaccine developed by scientists from the National Institutes of Health (NIH) or a placebo injection yielded starkly contrasting results. All 21 volunteers who received th... Read More

Researchers discover potential treatment for sepsis and other responses to infection

Researchers at the Icahn School of Medicine at Mount Sinai say that tiny doses of a cancer drug may stop the raging, uncontrollable immune response to infection that leads to sepsis and kills up to 500,000 people a year in the U.S. The new drug treatment may also benefit millions of people world... Read More

Microbial Genomics and the Future of Food Microbiology

There’s no question that foodborne disease is a serious problem. Illnesses from contaminated foods cause over 128,000 hospitalizations and 3,000 deaths each year in the United States. The Centers for Disease Control and Prevention estimates that one in six Americans suffers a food-related illne... Read More

BacterioFiles 283 - Phages Furnish Photosynthetic Fortifications

This episode: Viruses infecting photosynthetic bacteria could transfer immunity to other viruses between their hosts!


(6.8 MB, 7.4 minutes)


Show notes: 


Read More

Just a spoonful of L-arginine helps the biofilm go down

Many components of our oral hygiene regimens are meant to keep cariogenic bacteria at bay: sodium fluoride in ACT interferes with electron transport and ATP synthesis, the essential oils in Listerine have antiseptic effects, and abrasives – small, insoluble particles in toothpaste – help remove ... Read More

A promising Ebolavirus antiviral compound

Remember Ebolaviruses? Many people are still working on vaccines and therapeutics. Here is a very nice story on a promising antiviral compound that is very effective at preventing disease in monkeys. But it doesn't work in mice - it's degraded. You know what they say - mice lie, monkeys exaggera... Read More

Microbes of the Built Environment

ASM hosted a Twitter Chat on Microbes of the Built Environment. You may have missed the chat, but you can read the storified version of our conversation! See what our expert panelists had to say, and join us next time on ‪#‎ASMChats‬! http://bit.ly/27I9vH1 Read More

And now for something completely different: optimistic news from the world of antibiotic stewardship

There’s no way to avoid the news of a growing concern for drug-resistant infections. In both life-threatening and relatively superficial infections, the ability to successfully treat microbial infections with antimicrobials is decreasing. Our only recourse is to use the drugs we have carefully w... Read More

Climate change affects Swedish reindeer herding and increases tularemia

In northern Sweden, data from certain weather stations have shown that the snow season has been shortened by over two months in the last 30 years, which has huge effects on reindeer herding. Also, the climate sensitive human infection tularemia has tenfolded over the same period and is much more... Read More

Trinity immunologists find new ways to beat the 'bad guys'

Vaccines are like pathogen imposters - they mimic these 'bad guys' in order to provoke a response from our immune systems, remove the invader and begin the healing process.

One of the key components in a vaccine is an adjuvant, which serves to enhance our body's immune response to vaccination... Read More

TWiV 418: Of mice and MERS

The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor.


Hosts:  Read More

You Don’t Even Want To Know About Bacteria On The Space Station (video)

Think the ISS is squeaky clean...think again! Bacteria like Staphylococcaceae and Enterobacteriaceae absolutely thrive in space stations! Read More

A new vaccine has developed by Russia

Russian President Vladimir Putin claimed Wednesday his country had developed a vaccine for the Ebola virus which has killed thousands of people in west Africa.

But Putin, who is famed for his talent for headline-grabbing announcements, did not give any name for the vaccine, nor did he say how... Read More

TWiV 420: Orthogonal vectors

The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines.


Hosts: Vincent Racaniello Read More

HIV infection prematurely ages humans by an average of 5 years

Thanks to combination antiretroviral therapy, many people with HIV can be expected to live decades after being infected. Yet doctors have observed that these patients often show signs of premature aging. Now a study published April 21 in Molecular Cell has applied a highly accurate biomarker to ... Read More

UTMB researchers find how Ebola disables the immune system

A new study at The University of Texas Medical Branch in Galveston sheds light on how Ebola so effectively disables the human immune system.

Virologist Alex Bukreyev, UTMB professor and senior author of the study, said the research team engineered versions of the Ebola virus in order to study... Read More

An ancient killer: Ancestral malarial organisms traced to age of dinosaurs

CORVALLIS, Ore. - A new analysis of the prehistoric origin of malaria suggests that it evolved in insects at least 100 million years ago, and the first vertebrate hosts of this disease were probably reptiles, which at that time would have included the dinosaurs. Read More
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