It is universally accepted that the use of antibiotics will lead to antimicrobial resistance. Traditionally, the explanation to this phenomenon was random mutation and horizontal gene transfer and amplification by selective pressure. Subsequently, a second mechanism of antibiotic-induced antimic... Read More
Sixty years ago Jacob, Brenner and Cuzin devised their 'Replicon Model', inspiring and useful guideline for replication research ever since. According to the model, a 'Replicon' is a genetic element replicated from a single 'Replicator'—replication origin, in modern terms—and replication is trig... Read More
Infectious disease specialists at the Johns Hopkins Children’s Center have identified a protein that regulates the body’s immune response to cytomegalovirus (CMV), a common pathogen that causes lifelong infections and can lead to devastating illness in newborns and those with weakened immune sys... Read More
In a fascinating story that was presented on NPR by Nell Greenfieldboyce we learn that the source of the Justian Plague (541-543AD) was recently identified by sequencing blood extracted from the dental pulp of the teeth associated with two skeletons recovered from Munich. For many years it was... Read More
When most people look at soil, they just see dirt. When I look at soil, I see billions of microorganisms crawling atop one another, consuming the dead in a feasting frenzy that stops for nothing save a deep freeze. I see microbes and their enzymes, the digestive juices that break down, transform... Read More
We need to understand how diverse communities of microbes interact, but doing so in the gut is hard. Why not turn to a model system, where diverse microbial communities interact, but in an environment that’s easier to study? We have a long history of using model systems in biology – the mice I m... Read More
A four-year EU-funded project has identified new ways of cultivating marine microorganisms and screening them for potentially useful marine bio-compounds. This could have implications for the healthcare, cosmetics and pharmaceutical industries, which are just a few of the sectors that are eager ... Read More
Researchers have discovered that a type of white blood cell carries a deadly fungus into the brains of HIV positive patients, causing meningitis which kills more than 600,000 people a year. The discovery could lead to more effective ways of tackling the deadly fungus as it infects the human body... Read More
(Phys.org) —You may not recognize it by name, but if you have ever had a child with a diaper rash, that child was likely a host to Candida albicans (C. albicans). This unwelcome "guest" can be hard to control, as it can potentially lead to serious illness in humans with weakened immune systems. ... Read More
How handy would it be if, instead of taking your broken circuit board to the Genius Bar (again), you could just prompt it to heal itself? That’s the futuristic possibility researchers have recently inched ever so slightly toward, with the development of hybrid “living materials” made from bacter... Read More
An international team of scientists has identified the precise biochemical key that wakes up the body’s immune cells and sends them into action against invading bacteria and fungi.
The patented work, published in Nature today, provides the starting point to understanding our first line of defen... Read More
Fluoribacter bozemanae expressing blue-white fluorescence under long-wave UV light. If you look carefully one of the steaks does not fluoresce on the right hand side of the plate. The dark colony is actually Legionella pneumophila. Read More
While I was working on the “H1N-What?” post, I also knew there would soon be questions about MERS (Middle East Respiratory Syndrome), just as there were about SARS. So here are the essentials of what we know and don’t know about MERS—which has just been reported in the U.S.—as well as intriguing... Read More
Do you ever look at a couple and wonder… ‘Why are they together? What does X see in Y. I just don’t get it. Is X in it only for the money’? Who doesn’t at times ponder about such matters? There’s practically an entire economy based on it. However, you didn’t find this article while waiting to ... Read More
Researchers at the University of Virginia School of Medicine studying a potentially deadly parasitic infection have discovered a previously unknown way that human cells are killed, with the parasitic amoeba essentially nibbling cells to death – as a piranha might attack its prey.
Until now, r... Read More
Bravo Randy Schekman!
I strongly support your comments on the tyranny of "impact factors" and I will be pleased to join in efforts to prevent the misuse of these ratings.
Impact Factors have become a symbol of terror for scientists in all disciplines and their use in promotion and other ... Read More
Corralling desperados with names like bacillus and paenibacillus will require ingenuity and an arsenal of weapons. These outlaws aren't rustling cattle—they're making milk sour and cheese soft and crumbly.
For more than a century, milk has been heated to kill any bacteria or pathogens that ca... Read More
What have we learned?
The various comments confirm that the term microbiome means different things to different people.
Lita points out that in the early days when HMP was formed, the NIH officially defined the human microbiome as “all of the microorganisms and their genes and genomes whic... Read More
About 6,000 years ago, a bacterium underwent a few genetic changes. These allowed it to expand its habitat from the guts of mice to that of fleas. Such changes happen all the time, but in this particular instance the transformation eventually resulted in the Black Death that wiped out a third of... Read More
Prokaryotes are by far the most successful superkingdom in terms of both biochemical diversity and the variety of environments conquered. Bacteria can be found living in all kinds of adverse conditions; from high alkaline lakes, to below freezing temperature, to hot volcanic vents which in some ... Read More