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HIV patients should be included in early clinical trials of anti-TB drugs

Amsterdam, The Netherlands: Tuberculosis is the number one cause of death in HIV-infected patients in Africa and a leading cause of death in this population worldwide, yet the majority of these patients are excluded from the early stages in the development of new, anti-tuberculosis drugs, accord... Read More

TWiP 98 letters

Robin writes:


Balamuthia mandrillaris


http://www.cdc.gov/parasites/balamuthia/gen_info/faqs.html
Read More

TWiV 385: Failure

Hosts: Vincent Racaniello and Dickson Despommier


Guest: Stuart Firestein Read More

Honoring the Memory of Another

The late Edward Leadbetter had a huge impact on my life as an academic, and a microbiologist. In this post, I try to give some appreciation to what he meant to me. Read More

Biologist investigates how gene-swapping bacteria evade antibiotics

A scientific peek into bacteria boudoirs is revealing how "sex" among disease-causing microbes can lead different species or strains to become resistant to antibiotic medications. Read More

BacterioFiles 251 - Mycophagous Myrmicinae Mutualist Microbes

This episode: Gut bacteria seem to help ants with very restrictive diets flourish more!


(10.6 MB, 11.5 minutes)


Show notes: 
Journal Paper


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Sendai virus defends against a threat

A research group at Hiroshima University demonstrated the mechanism by which the Sendai virus (SeV) escapes the host immune system. The researchers examined the crystal structure of the complex of SeV C protein and transcription factor STAT1, and found that SeV C protein inhibits the signal tran... Read More

Plague infected humans much earlier than previously thought

Plague infections were common in humans 3,300 years earlier than the historical record suggests, reports a study published October 22 in Cell. By sequencing the DNA of tooth samples from Bronze Age individuals from Europe and Asia, the researchers discovered evidence of plague infections roughly... Read More

TWiV 394: Cards in a hand

Vincent and Alan speak with Erica Ollmann Saphire about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.


Hosts:  Read More

New smart drug targets and reduces site-specific inflammation

BEER-SHEVA, Israel...July 22, 2015 - Ben-Gurion University of the Negev (BGU) and University of Colorado researchers have developed a dynamic "smart" drug that targets inflammation in a site-specific manner and could enhance the body's natural ability to fight infection and reduce side effects. Read More

NYU research: Severe liver damage in mid/late-adulthood among PWID with chronic HCV

The Hepatitis C virus (HCV) infection is a chronic blood-borne viral infection that affects an estimated 160 million people, or 2-3% of the population world-wide. Alarmingly, chronic HCV infection accounts for one-quarter of the cases of cirrhosis and hepatocellular carcinoma (HCC). If HCV is le... Read More

Portraits of Microbiologists Using Luminous Bacteria as "Paint."

My wife Jennifer Quinn​ hits it out the park: a portrait of Kenneth Nealson​ and the late Woody Hastings "painted" with luminous bacteria, giving them props for the early days of quorum sensing---where the basic principles were first uncovered in bioluminescent microbes. This principle of "aut... Read More

Study finds state policies influence vaccination, disease outbreak rates

Athens, Ga. - Lax state vaccination laws contribute to lower immunization rates and increased outbreaks of preventable diseases--like whooping cough and measles--according to a new study from the University of Georgia. Read More

Study: Breastfeeding could reduce common infections among Indigenous infants

TORONTO, Aug. 17, 2015--Promoting breastfeeding could lead to a substantial reduction in common infections and even deaths that are more common in Indigenous infants than non-Indigenous infants, a new study suggests. Read More

New Drug for Lung Cancer can Improve the Survival Rate Greatly

BOC Sciences-Scientists have found a drug called nivolumab more effective for non-small cell lung cancer, as it increases the survival time while bring less side effects than the traditional drug used for non-small cell lung cancer. Read More

Compound from Red Wine is Helpful to Slow the Development of Alzheimer

BOC Sciences-Alzheimer is one of the most common diseases among the elderly as aging playing a contributing role in the developing process of it. Recently scientists found a natural compound beneficial to slow down the deterioration and treatment of Alzheimer. At present a phase 2 study is carri... Read More

TWiV 378: Herpes plays DUBstep

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and  Read More

Wibbly-wobbly-timey-wimey

A Time Lord needs his TARDIS to embark on fantastic discoveries. These LB agar plates contain a colorless reagent called X-gal, which is the sugar galactose linked to a dark blue dye. Some microbes can synthesize an enzyme (β-galactosidase) that snips the X-gal in two, releasing the blue color a... Read More

TWiM #127: Subway Snowblowers and Men in Black

The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease.


Image (right): Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white ‘snow’ in the vent a... Read More

ZIKA VIRUS ‘IS ABOUT AS SCARY AS IT GETS’

The Zika virus, unlike other mosquito-borne viruses such as dengue, has until now been relatively unknown and unstudied. Read More
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