Bacteria can evolve rapidly to adapt to environmental change. When the "environment" is the immune response of an infected host, this evolution can turn harmless bacteria into life-threatening pathogens. A study published on December 12 in PLOS Pathogens provides insight into how this happens.
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The genome of viruses is usually enclosed inside a shell called capsid. Capsids have unique mechanic properties: they have to be resistant and at the same time capable of dissolving in order to release the genome into the infected cell. The scientists of the International School for Advanced Stu... Read More
A protein in Salmonella inactivates mast cells -- critical players in the body’s fight against bacteria and other pathogens -- rendering them unable to protect against bacterial spread in the body, according to researchers at Duke Medicine and Duke-National University of Singapore (Duke-NUS).
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This article discusses the famous pump handle that John Snow may or may not have had removed ... read the article to get the true story. From medical historian Peter Vinten-Johansen. Read More
It is universally accepted that the use of antibiotics will lead to antimicrobial resistance. Traditionally, the explanation to this phenomenon was random mutation and horizontal gene transfer and amplification by selective pressure. Subsequently, a second mechanism of antibiotic-induced antimic... Read More
The abilities of bacterial organisms to utilize the various strategies to resist antimicrobial compounds are all genetically encoded.
Intrinsic resistance is that type of resistance which is naturally coded and expressed by all (or almost all) strains of that particular bacterial species. An... Read More
Methicillin-resistant S. aureus (MRSA) constitutes approximately 50% of clinical S. aureus isolates and is most commonly the result of production of a mutated pencillin-binding protein, PBP2a, which is able to carry out essential cell wall synthesis functions while maintaining a low-affinity for... Read More
Antibiotic resistance mechanisms of clinically important bacteria. Read More
"Clinically Important Drug-Resistant Bacteria” Read More
Genomes provide clues for treating leukemia, endometrial cancers
New research reveals the complex dynamic between gut bacteria and the immune system that keeps proteins from flagellin—bacterial tails—under control.
In healthy individuals, the only thing that separates the lining of the human gut from the some 100 trillion bacterial cells in the gastrointes... Read More
A boy with cystic fibrosis develops a chronic and potentially deadly Burkholderia dolosa infection in his lungs. Varieties of genetic mutations allow some strains of the bacteria to survive the dual assaults from his immune system and antibiotics, while others perish. Eventually, the strongest m... Read More
Getting the message out to the public that the microbial world is about much more than just diseases is a challenging topic, but one we should keep trying to improve on. There are many ways to do this, but as the saying goes, a picture is worth a thousand words, and most people don’t want to rea... Read More
Otherwise innocuous bacteria can cause deadly infections when people have surgery or fall ill. To prevent trouble, patients sometimes have their bodies scrubbed clean of Staphylococcus aureus. But it doesn't always work.
That may because the germs thrive in upper recesses of the nose, far fro... Read More