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TWiM 142 Letters

Carole writes:


Dear Vincent and hosts of TWIM,


I am a long time listener and fan of your weekly TWIM podcasts. I really enjoyed the latest episode in which you discussed a paper by Kelly Wrighton and colleagues, and was especially... Read More

My first year at the wheel: reflections on ASM

Perhaps with more enthusiasm than originality, I feel compelled at the end of the year to look back on what has happened in my life. The compulsion is even stronger this December, since the end of the calendar year coincides with my first year at the helm of ASM as its CEO.

When I joined AS... Read More

TWiV 421: Like flies on shot

The TWiVnauts present another example of an infectious but replication incompetent vaccine, an insect specific arborvirus bearing chikungunya virus structural proteins.


Hosts: Vincent Racaniello,&n... Read More

Bacteria in your mouth may trigger arthritis

Investigators at Johns Hopkins report they have new evidence that a bacterium known to cause chronic inflammatory gum infections also triggers the inflammatory “autoimmune” response characteristic of chronic, joint-destroying rheumatoid arthritis (RA). The new findings have important implication... Read More

Tuberculosis virulence factor identified, may be target for new drug

Scientists have discovered the mechanism that hijacks the immune system's response to tuberculosis, revealing an important new drug target for the disease that kills more than 1 million people each year.

Herman Sintim, Purdue University's Drug Discovery Professor of Chemistry, collaborated wi... Read More

Zika-linked birth defects more extensive than previously thought, UCLA-led research finds

New UCLA-led research finds that Zika-linked abnormalities that occur in human fetuses are more extensive — and severe — than previously thought, with 46 percent of 125 pregnancies among Zika-infected women resulting in birth defects in newborns or ending in fetal death.

The study, published ... Read More

CRISPR screening identifies potential HIV treatment targets

Investigators from the Ragon Institute of MGH, MIT and Harvard and the Broad Institute of MIT and Harvard have used the revolutionary new gene-editing technology CRISPR-Cas9 to identify three promising new targets for treatment of HIV infection. In their report receiving advance online publicati... Read More

You Don’t Even Want To Know About Bacteria On The Space Station (video)

Think the ISS is squeaky clean...think again! Bacteria like Staphylococcaceae and Enterobacteriaceae absolutely thrive in space stations! Read More

First chikungunya vaccine from virus that does not affect people

Researchers from The University of Texas Medical Branch at Galveston have developed the first vaccine for chikungunya fever made from an insect-specific virus that doesn’t have any effect on people, making the vaccine safe and effective. The newly developed vaccine quickly produces a strong immu... Read More

Protein that activates immune response harms body's ability to fight HIV

n findings they call counterintuitive, a team of UCLA-led researchers suggests that blocking a protein, which is crucial to initiating the immune response against viral infections, may actually help combat HIV.

Findings from a study in animals appear to demonstrate that temporarily blocking a... Read More

Genomic sequencing illuminates recent Shigella outbreaks in California

In a study that could have significant impact on how disease outbreaks are managed, researchers at UC Davis and the California Department of Public Health (CDPH) have sequenced and analyzed genomes from Shigella sonnei (S. sonnei) bacteria associated with major shigellosis outbreaks in Californi... Read More

Scientists learn how to ramp up microbes' ability to make memories

Some microbes can form memories—although, inconveniently for scientists who study the process, they don’t do it very often.

Rockefeller University researchers and their colleagues at the University of California, Berkeley, have found a way to make bacteria encode memories much more frequently... Read More

TWiV 422: Watching the icosahedron drop

The TWiVestigators wrap up 2016 with a discussion of the year's ten compelling virology stories.


Hosts: Vincent Racaniello Read More

Reconstructing a lichen's molecular architecture

Chemist Pieter Dorrestein’s laboratory group has been developing mass spectrometry methods to look at what molecules are produced by microbes interacting in a petri dish. But recently, the group jumped out of the dish and into the dirt—to analyze a soil-dwelling lichen and discover how the molec... Read More

TWiV 420: Orthogonal vectors

The TWiV gurus describe how to use an orthogonal translation system to produce infectious but replication-incompetent influenza vaccines.


Hosts: Vincent Racaniello Read More

TWiM #142: A membrane-thickness caliper

Vincent, Elio and Michele wind up a year of microbial podcasts with a story about the lack of resistance to a crop antifungal compound, and how a bacterium uses a molecular caliper to measure membrane thickness.


Hosts:  Read More

Nativity!

Marry Christmas!
Nativity was recreated with Saccharomyces cerevisiae. Read More

Why odds are against a large Zika outbreak in the US

Is the United States at risk for a large-scale outbreak of Zika or other mosquito-borne disease? While climate conditions in the U.S. are increasingly favorable to mosquitos, socioeconomic factors such as access to clean water and air conditioning make large-scale outbreaks unlikely, according t... Read More

Know thy enemy: Kill MRSA with tailored chemistry

UConn medicinal chemists have developed experimental antibiotics that kill MRSA, a common and often deadly bacteria that causes skin, lung, and heart infections. The success is due to their strategy, which found a weakness and exploited it in a way the bacteria should have trouble countering, th... Read More

Happy New Year 2017

This is our way to wish a Happy New Year to all the Microbiologists community!
The numbers were made as follows:
2: E. coli, MacConkey Agar plate incubated at 37 C, 20h.
0,1: MRSA on blood Agar plate, incubated at 37 C + 5%CO2.
7: M. fortuitum on Chocolate Agar plate, incubated at 37 C + 5%... Read More
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