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E. coli Cells Face FACS and Get Back into Shape

There’s no question that variation in size and shape has conferred selective advantages over the course of evolutionary time. One of the most obvious examples is the long neck and legs of the giraffe, which allow it to snatch foliage that is unreachable by vertically challenged competitors. The ... Read More

New study shows how Salmonella colonises the gut

Salmonella is a major cause of human diarrhoeal infections and is frequently acquired from chickens, pigs and cattle, or their products. Around 94 million such infections occur in people worldwide each year, with approximately 50,000 cases in the UK per annum.

In a BBSRC-funded collaboration ... Read More

High-powered microscopic techniques give scientists detailed view of a critical component of cellular infrastructure

The cellular interior is criss-crossed by protein-based cables known as microtubules, each formed from 13 'protofilaments' composed of the protein tubulin. Microtubules are also associated with a host of other specialized proteins that help coordinate the transport of molecular cargoes and link ... Read More

Genital Wart Rate in Young Women Plummets Thanks to HPV Vaccine, Claim Researchers

The proportion of young women diagnosed with genital warts in Australia has seen a significant decline thanks to the HPV vaccine, suggests a new paper. In 2007, Australia became one of the first countries to implement a nationally funded quadrivalent human papillomarivus (HPV) vaccination progra... Read More

Episode 7: All Life on Earth Depends on Microbes

This video describes the role of microbes in the production side of the global food web. Microbes transform essentially inert gaseous nitrogen into active nitrogen compounds, which then go on to make amino acids and proteins. Read More

Despite Superbug Crisis, Progress in Antibiotic Development 'Alarmingly Elusive'

Despite the desperate need for new antibiotics to combat increasingly deadly resistant bacteria, the U.S. Food and Drug Administration (FDA) has approved only one new systemic antibiotic since the Infectious Diseases Society of America (IDSA) launched its 10 x ’20 Initiative in 2010 — and that d... Read More

Recreational use of HIV antiretroviral drug linked to its psychoactivity

Efavirenz (tradenames: Sustiva, Stocrin) is an antiretroviral (ARV) drug commonly used to treat HIV. Its popularity as a medication, alone or more commonly in combination with other HIV medications (tradename: Atripla), is due to its superior effectiveness in suppressing replication of the virus... Read More

Hilary Koprowski, Who Developed First Live-Virus Polio Vaccine, Dies at 96

It was a brew to rival any in “Macbeth.” The main ingredients were rat brain and a fearsome, carefully cultivated virus.

In his laboratory in Pearl River, N.Y., 20 miles north of Manhattan, Dr. Hilary Koprowski macerated the ingredients in an ordinary kitchen blender one January day in 1948. ... Read More

Beer Pong Balls Carry Bacteria, Proving Game Disgusting

Clemson University researchers found that beer pong balls may carry dangerous bacteria, The Associated Press reported.

The balls collected by student researchers from parties over one weekend found salmonella, listeria, E. coli and staph, according to the AP. The study found a high level of b... Read More

TWiV 229: Partly cloudy with a high of H7N9



Hosts: Vincent Racaniello, Rich Condit, Read More

BacterioFiles Micro Edition 122 - Coliforms Consume Caffeine Compulsively

This episode: Scientists engineer E. coli to be addicted to caffeine!




Download Episode (4.3 MB, 4.75 minutes)


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Student Creativity and Student Study Guides

In this blog entry, I discuss the perennial problem for educators: helping students find study strategies that help them reach their educational goals. I have found that student-generated study material is most helpful...and is sometimes quite artistic! Read More

New coronavirus treatable with a mix of antiviral drugs, immune boosters: health experts

When a new disease emerges, scientists and physicians hope something that’s already in the medicine cabinet can be used to treat it.

A new study suggests for the novel coronavirus, that may be the case.

Scientists from the U.S. National Institute of Allergy and Infectious Diseases are repo... Read More

H7N9 Bird Flu Cases In China Rise By Four To 91; Half Have Had No Contact With Poultry

The number of confirmed H7N9 bird flu cases in China increased by four to 91 on Friday. Jiangsu province reported one new case, and Zhejiang province reported three, the state-run Shanghai Daily reported today. The number of dead was unchanged at 17.

An increasing focus among public health ... Read More

TWiP 53 Letters

John writes:


Dear Vincent and Dickson,


I just heard your most recent TWIP. Please keep these podcasts going! I love listening to your podcasts and hearing your enthusiasm for my favorite biological topic, parasites. Remember that for every fan... Read More

TWiP 53: Anti-saliva immunity



Hosts: Vincent Racaniello and Dickson Despommier


Vincent and Dickson discus... Read More

High steaks

Those who take part in clinical trials often have to do nasty things, from taking new drugs to forgoing sleep. Participants in a trial organised by Stanley Hazen of the Cleveland Clinic, in Ohio, had a decidedly easier task: eating steak. After reading Dr Hazen’s conclusions, though, they may be... Read More

Role of Gut Microbiome in Pediatric GI Disease: Evidence Suggestive, But Not Conclusive

Intestinal dysbiosis may play a role in gastrointestinal (GI) disorders such as necrotizing enterocolitis (NEC) and irritable bowel syndrome (IBS) in children, and prebiotics and probiotics may be efficacious for treating these conditions, according to Philip M. Sherman, MD, professor of pediatr... Read More

Modified bacteria could be used in vaccines

A modified strain of Salmonella could be used to efficiently deliver antigens, the key ingredients of vaccines, into human cells, a study suggests.

Salmonella bacteria use nanoscopic needles to inject their own proteins into host cells, enabling them to survive and replicate inside those cell... Read More

Quest for Edible Malarial Vaccine Leads to Other Potential Medical Uses for Algae

Can scientists rid malaria from the Third World by simply feeding algae genetically engineered with a vaccine?

That’s the question biologists at UC San Diego sought to answer after they demonstrated last May that algae can be engineered to produce a vaccine that blocks malaria transmission. I... Read More

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