E. coli usually brings to mind food poisoning and beach closures, but researchers recently discovered a protein in E. coli that inhibits the accumulation of potentially toxic amyloids—a hallmark of diseases such as Parkinson's.
Amyloids are formed by proteins that misfold and group together, ... Read More
Paul Duprex joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis.
Researchers at Harvard and Yale have used some extreme gene-manipulation tools to engineer safety features into designer organisms.
This work goes far beyond traditional genetic engineering, which involves moving a gene from one organism to another. In this case, they're actually rewriting th... Read More
The deadly pattern of illnesses began to emerge in 2012 at hospitals in Seattle, Pittsburgh, Chicago. In each case, the culprit was a bacteria known as CRE, perhaps the most feared of superbugs, because it resists even "last defense" antibiotics — and kills up to 40% of the people it infects.
... Read More
Vincent, Dickson, and Daniel provide the solution to last week's case study, present a new one, and discuss how immune suppression by nematodes increases tuberculosis fatality in African buffalo.
Dear Vincent & Dickson… and Daniel,
I always enjoy listening to TWIP here in Kona, Hawaii.
Our weather today is 79ºF and clear but we have just experienced a record 25-year overnight low of 54ºF,
Acid Fast stain done on a mix of Staphylococcus aureus and Mycobacterium smegmatis. The stain was done on a culture of M. smegmatis that was incubated on a TSA slant with 1ml TSB added at 37 degree's C for 4 days, S. aureus was incubated in TSB at 37 degree's C for 24 hrs. Several loops of eac... Read More
Scientists looking for Ebola in bats have identified 16 other viruses in the animal which could jump to humans and potentially cause a disease outbreak on a similar scale to the West African crisis, a health security expert said on Friday.
Humans can contract Ebola from bats, which are carrie... Read More
Viruses are incredibly simple, arguably the most simple living organisms on the planet. They have no brains, no metabolism, and they can’t reproduce on their own. Yet they are able to wreak incredible havoc on our bodies and to outwit the scientifically advanced weapons that humans have invente... Read More
Researchers from UAB have developed a tool for diagnosing bacterial meningitis that uses the same technology as a home pregnancy test.
The test measures the level of certain proteins that are present in the spinal fluid of patients with bacterial meningitis. If the level is high, the test wil... Read More
Satellites are subviral agents that differ from viroids because they depend on the presence of a helper virus for their propagation. Satellite viruses are particles that contain nucleic acid genomes encoding a structural protein that encapsidates the satellite genome. Satellite RNAs do not encod... Read More
Clinical microbiology consists of a wide array of techniques for the detection of infectious diseases. The respiratory diseases segment accounted for the largest application segment of the clinical microbiology market in 2014. According to the WHO, in 2012, there were about 450,000 new cases of ... Read More
We all know about selfies, made popular by the camera in our cell phone. Well, here is the *real* deal - the 'cell-fie'. It's a photograph of my cell culture incubator full of stacks of plates in which HeLa cells are growing - and it's complete with my reflection. Read More
Hosts: Vincent Racaniello
Special guest: Rob Knight
Vincent meets up with Rob Knight to talk about the technology that has... Read More
Pictured is a culture of Mycobacterium tuberculosis growing colonies in the distinctive "serpentine cord" form seen in many strains of M. tuberculosis. These cords are made up of chains of cells that make chains due to a cell wall factor of MTB.
The cell wall structure of Mycobacterium is a m... Read More
Simple stain done on an unknown bacteria, showing feathery rhizoid growth on TSA after a 48 hr incubation at 37 degree’s C, isolated from a floor swab. Single bacillus and diplobacillus can be seen though out. Read More
Two miles below the surface of the ocean, researchers have discovered new microbes that “breathe” sulfate.
The microbes, which have yet to be classified and named, exist in massive undersea aquifers — networks of channels in porous rock beneath the ocean where water continually churns. About ... Read More
Previous research has already demonstrated that substantial quantities of self-motile or active agents such as bacteria in a fluid environment can be harnessed to do mechanical work like moving microscopic gears and ratchets. Bacteria as well as algae can also be used to transport or displace ma... Read More
If thinking about the billions of bacteria taking up residence in and on your body gives you the willies, you probably won’t find it comforting that humans are also full of viruses. These maligned microbes are actually intertwined in the very fibers of our being—about 8 percent of our genetic ma... Read More
Genomes of non-defective viruses range in size from 2,400,000 bp of dsDNA (Pandoravirus salinus) to 1,759 bp of ssDNA (porcine circovirus). Are even smaller viral genomes possible? The subviral agents called viroids provide an answer to this question.
Viroids, the smallest known pathogens, ar... Read More