The Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) is the annual infectious diseases meeting of the American Society for Microbiology. Watch Dr. Jeff Fox, Features Editor for Microbe magazine interview researchers on selected topics of interest from the meeting in San Francisco. This webpage will broadcast the daily webcasts being held September 9-11, 2012, at the Moscone Center (North and South) in Room 303. For more information about ICAAC please visit www.icaac.org. If you are a member of the press visit the ICAAC newsroom to register for the meeting.
In addition, Vincent Racaniello of This Week in Microbiology will be broadcasting special edition of ICAAC Live on Monday, Sept. 10 at 2 p.m., PDT.
Meeting attendees are welcome to attend and watch the live broadcasts as well as submit questions to the researchers.
All interviews will be archived online at YouTube and here on MicrobeWorld.
(Press play to start. To ask a question please tweet @ASMNewsroom. You can also use the hash tag #ICAAC.)
(Please note topics, guests and times are subject to change. This page may be updated frequently prior to ICAAC.)
Seasonal flu vaccines are targeted for strains of the influenza virus that public health officials believe will be most prevalent in the upcoming season. While the vaccine primes the immune system to protect against those specific strains, what does it mean for other future strains of the virus. Researchers will present findings from a study showing ferrets who received the 2008-2009 seasonal vaccine experienced a more severe disease when exposed to the pandemic H1N1 influenza virus than ferrets who did not receive the vaccine.
Since the introduction of highly active antiretroviral therapy in the mid-1990s, HIV infection has evolved from a near-certain death sentence to a manageable, chronic disease. Still, little is known about the long-term effects of HIV on human health. Two studies being presented today on cardiovascular health and HIV suggest that HIV-infected patients develop cardiovascular disease at a much earlier age than those without HIV and are more likely to die after hospital admission for a heart attack.
Daniel Pearce, Loma Linda University, Loma Linda, CA, United States
Charles Hicks, Duke University Medical Center, Durham, NC, United States
Although as recently as 1980 measles was estimated to cause 2.6 million deaths globally, due to highly effective and safe vaccines, measles elimination has been achieved in a number of countries globally as well as in the region of the Americas. Expansion of measles control strategies and activities has resulted in substantial gains in measles vaccine coverage globally with accompanying declines in measles disease burden and mortality. Despite these successes, recent setbacks have occurred due to under-vaccination, including large measles outbreaks in Africa and Europe. This resurgence of measles has resulted in increases in measles virus importations in countries that have achieved measles elimination; 1,380 measles cases were provisionally reported in the Americas during 2011, the highest number of measles cases reported since 2002. Participants will discuss what needs to be done to reverse these trends, and achieve milestones set for 2015 toward the goal of measles eradication as well as recent research that suggests children who receive their first measles vaccination at 12 months are more likely to contract the disease as adolescents than those who receive at 15-16 months.
Jane Seward, Centers for Disease Control and Prevention, Atlanta, GA, United States
Gaston De Serres, Institute National de Santé Publique du Quebec, Quebec, Canada
Current influenza vaccines are limited because they can only stimulate immunity to specific strains of the virus, which is constantly evolving. This means a new vaccine must be developed every year to target the strains public health officials believe will be most prevalent that season. If an unforeseen strain emerges the vaccine would provide little or no protection. For that reason the “holy grail” of public health is the development of a universal influenza vaccine, one that can provide protection against any potential strain of the virus. Researchers will discuss current efforts underway and the most recent developments on the road to a universal flu vaccine.
There is a long history of anecdotal evidence to suggest that cranberries and other alternative therapies to long-term antibiotics can prevent recurrent urinary tract infections but are they really as effective as antibiotics or even a viable alternative for people who do not want to take antibiotics for prevention. Researchers will present the results of two interlinked trials involving nearly 500 women in the Non-antibiotic versus Antibiotic Prophylaxis for Recurrent Urinary Tract Infections (NAPRUTI) Study.
2:00 p.m., PDT - ICAAC Live: This Week in Microbiology with Vincent Racaniello
The hosts for the podcast This Week in Microbiology, Vincent Racaniello and Michael Schmidt, will be joined by William Bishai, John Brownstein, and Victor Nizet to discuss the regulation of virulence factors in the pathogenesis of tuberculosis, the emerging role of social media in public health, and outside-the-box approaches to antibacterial therapy, such as targeting virulence factors or boosting innate immune function, with Streptococci and Staphylococci as the primary models.
Clostridium difficile infection is an important cause of intestinal disease, primarily affecting hospitalized patients exposed to antibiotics. Infection has been associated with prolonged hospital stays and excess healthcare expenditures. In recent years, C. difficile infections have become more frequent, more severe and more difficult to treat. Participants discuss one promising new treatment option, the development of human monoclonal antibodies that target either the bacterium itself or the toxin it produces.
Sylvia Wong, Donnelly Centre for Cellular & Biomolecular Research, University of Toronto, Toronto, ON, Canada
David Humphreys, UCB Pharma, Slough, United Kingdom
10:30 a.m., PDT - Emergence of Animal-Origin H3N2 Influenza
Public health officials will provide the latest update on the H3N2, the new strain of influenza that appears to have jumped from swine to humans and has already infected nearly 300 people in the United States.
Over the past fifteen years, Internet technology has significantly changed the landscape of public health surveillance and epidemic intelligence gathering. Disease and outbreak data is disseminated not only through formal online announcements by government agencies, but also through informal channels such as social networking sites, blogs, chat rooms, Web searches, local news media and crowdsourcing platforms. Dr. Brownstein will discuss the current capabilities and future directions in the use of the non-traditional data sources for the purposes of public health surveillance and rapid detection of emerging infectious diseases.
John Brownstein, Children's Hospital Boston & Harvard Medical School, Boston, MA, United States