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TWiP 98 letters

Robin writes:


Balamuthia mandrillaris


http://www.cdc.gov/parasites/balamuthia/gen_info/faqs.html
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Guinea reports Ebola-free week, but Sierra Leone has 5 cases

For the first time in more than a year, Guinea passed a week without a new lab-confirmed Ebola case, but the news out of West Africa last week was tempered by a flare-up of activity in Sierra Leone, the World Health Organization (WHO) reported today in its latest update. Read More

TWiM #124: Fungal pirates

Hosts: Vincent Racaniello, Michele Swanson, and Michael Schmidt.


Vincent, Michael, and Michele reveal how a fungal protease blunts the innate immune response and promotes pathogenicity. 


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Tardigrade genome sequencing reveals unprecedented horizontal gene transfer

Tardigrades are small animals (~1.5 mm in length) renowned for their ability to survive in many extreme environments. From wikipedia "...they can withstand temperatures from just above absolute zero to well above the boiling point of water (100 °C), pressures about six times greater than those ... Read More

Asymptomatic people can transmit Dengue viruses to Mosquitos

75% of the ~390 million people infected with dengue viruses present with no symptoms (asymptomatic). It is generally assumed that these asymptomatic infections cannot be transmitted to mosquitos. Not only does this study show that people with asymptomatic infections transmitted the virus to mo... Read More

Infectious diseases bring millions of elderly to emergency departments each year

Investigators estimate that during 2012, there were more than 3.1 million emergency department visits for infectious diseases among elderly US adults. Read More

TWiV 341: Ebolavirus experiences

Host: Vincent Racaniello


Guests: Adam Kucharski Read More

MdlM116: La importancia de los virus como patógenos emergentes en América Latina

Los virus son considerados por la mayoría como patógenos en todo tipo de entidades biológicas.  Sin embargo la gran mayoría de los virus son inocuos a sus células hospedero.  Nuestro invitado de hoy, el Dr. Paolo Zanotto es investigador y profesor en la Universidad de Sao Paolo, Bra... Read More

'Ensemble' modeling could lead to better flu forecasts, study finds

By combining data from a variety of non-traditional sources, a research team led by computational epidemiologists at Boston Children's Hospital has developed predictive models of flu-like activity that provide robust real-time estimates (aka "now-casts") of flu activity and accurate forecasts of... Read More

Vitamin D deficiency may limit immune recovery in HIV-positive adults

Athens, Ga. - A University of Georgia researcher has found that low levels of vitamin D may limit the effectiveness of HIV treatment in adults. Read More

Breast cancer drug beats superbug

Researchers at University of California, San Diego School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences have found that the breast cancer drug tamoxifen gives white blood cells a boost, better enabling them to respond to, ensnare and kill bacteria in laboratory experiment... Read More

Microbiomes could hold keys to improving life as we know it

A consortium of 48 scientists from 50 institutions in the United States - including Pamela Silver, Ph.D., a Core Faculty member at the Wyss Institute for Biologically Inspired Engineering at Harvard University - are calling for a Unified Microbiome Initiative that would span national cross-insti... Read More

Wibbly-wobbly-timey-wimey

A Time Lord needs his TARDIS to embark on fantastic discoveries. These LB agar plates contain a colorless reagent called X-gal, which is the sugar galactose linked to a dark blue dye. Some microbes can synthesize an enzyme (β-galactosidase) that snips the X-gal in two, releasing the blue color a... Read More

Clostridium difficile in the domicile

Patients undergoing FMT have often suffered for years prior to the therapy. If their homes have been contaminated with the eradicated microbe, could patients suffer a relapse by way of reinoculation? This was the question asked by a group of physician scientists, whose findings were recently pub... Read More

TWiP 104: La maladie du sommeil

Michael returns to help the TWiP trio solve the case of the Delusional African Expatriate, who then discuss the association of natural and induced antibodies in mice with differential susceptibility to secondary cystic echinococcosis.


Hosts:  Read More

NIH-sponsored clinical trial of chikungunya vaccine opens

An experimental vaccine to protect against the mosquito-borne illness chikungunya is being tested in a Phase 2 trial sponsored by the National Institutes of Health. Results from an initial trial of the vaccine, which was developed by scientists at the NIH National Institute of Allergy and Infect... Read More

Scientists are Working on Making Drugs More Biodegradable

BOC Sciences-Wild animals were found carrying drug resistance though they are living in areas where few human activities are existing. This finding makes scientists think about how to prevent the situation from deteriorating and protect water from being polluted furtherly. From the previous blog... Read More

New SARS-like virus can jump directly from bats to humans, no treatment available

Researchers from the University of North Carolina at Chapel Hill have discovered a new bat SARS-like virus that can jump directly from its bat hosts to humans without mutation. However, researchers point out that if the SARS-like virus did jump, it is still unclear whether it could spread from h... Read More

TWiV 338: Coyotes have sushi

Hosts: Vincent Racaniello and Kathy Spindler


Guest:  Read More

MGH team broadens utility of more compact CRISPR-Cas9 by increasing its targeting range

A team of Massachusetts General Hospital (MGH) investigators has shown that a method they developed to improve the usefulness and precision of the most common form of the gene-editing tools CRISPR-Cas9 RNA-guided nucleases can be applied to Cas9 enzymes from other bacterial sources. In a paper r... Read More
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