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New Compound for Alcoholism Treatment

BOC Sciences-A new beta-carboline compound shows great potential for alcoholism treatment. At present, no side effects caused by the new compound have been found in the trials on rats. The compound was developed by research team from Wisconsin in Milwaukee, US. With further successful tests and ... Read More

Tripped up by a bug: Infection may cause falls, especially in older people, study suggests

SAN DIEGO - People who end up in the emergency room because of a fall often are tripped up by an infection, rather than a loose throw rug or poor eyesight, suggests a study being presented at IDWeek 2015™. Read More

NIH-funded study establishes genomic data set on Lassa virus

An international team of researchers has developed the largest genomic data set in the world on Lassa virus (LASV). The new genomic catalog contains nearly 200 viral genomes collected from patient samples in Sierra Leone and Nigeria, as well as field samples from the major animal reservoir, or h... Read More

Decontamination Exterminates Antibiotic Resistant Bacteria from Pig Farm

Washington, DC – September 4, 2015 - Decontamination protocols eradicated both methicillin-resistant Staphylococcus aureus (MRSA) and antibiotic resistant, pathogenic intestinal bacteria, the Enterobacteriaceae, from a pig farm. The research appears online September 4th in ASM’s journal Applied ... Read More

Molecular 'kiss of death' flags pathogens

DURHAM, N.C. -- Many bugs that make us sick -- bacteria, viruses, fungi and parasites -- hide out in our cells in protective little bubbles called vacuoles. To clear an infection, the immune system must recognize and destroy these vacuoles while leaving the rest of the living cell intact. Read More

'Clever adaptation' allows yeast infection fungus to evade immune system attack

Johns Hopkins Bloomberg School of Public Health researchers say they have discovered a new way that the most prevalent disease-causing fungus can thwart immune system attacks. Read More

BacterioFiles 256 - Virus Versus Virus

This episode: Viruses can cause host cells to inhibit other viruses!


(8 MB, 8.75 minutes)


Show notes: 
Journal Paper:

Chiba S, Suzuki N. 2015. Highly act... Read More

Flu vaccine reduces hospitalizations and deaths among nursing home residents

When the influenza vaccine is well matched to the prevailing strains of flu in a given season, patients in nursing homes are significantly less likely to be hospitalized or to die of pneumonia and other influenza related causes. The finding comes from a study of more than 1 million Medicare fee-... Read More

TWiM 127 Letters

Stefan writes:


Just discovered this nice episode.
Well made and nicely discussed comment on our pack-hunting paper; quick reply to the question what would happen if you add one single amoebae: it would multiply and a clonal pack would do the same thing as observe... Read More

Role of breast cell infection in flu transmission between mothers and breast-feeding ferrets

Influenza is known as an infectious respiratory disease, but a study published on October 8th in PLOS Pathogens suggests that infected cells in breast tissues could play a role in virus transmission from mothers to breast-feeding infants and vice versa using a ferret model. Read More

Gerilizumab IL-6 is Put into Human Trial for Rheumatoid Arthritis

BOC Sciences-Recently, a biotechnology company announced that gerilizumab IL-6 as a drug for rheumatoid arthritis was under trial in healthy people. Once the safety is proved in human trial, gerilizumab will be a better alternative for rheumatoid arthritis both in effect and cost. Read More

TWiM #127: Subway Snowblowers and Men in Black

The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease.


Image (right): Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white ‘snow’ in the vent a... Read More

Hibernating bats mount a partial immune response against white nose fungus

White-nose syndrome (WNS), an invasive skin infection caused by the Pseudogymnoascus destructans (Pd) fungus has killed millions of bats since it was first seen in North America in 2007. A analysis of gene expression in hibernating bats infected with the destructive fungus published on October 1... Read More

HIV cure research: NIH scientists create 2-headed protein to deplete HIV reservoir

Scientists at the National Institutes of Health (NIH) have created a protein that awakens resting immune cells infected with HIV and facilitates their destruction in laboratory studies. The protein potentially could contribute to a cure for HIV infection by helping deplete the reservoir of long-... Read More

Notch Inhibitors are Potential for Cancer Treatment Studies Found

BOC Sciences-Notch inhibitors like gamma-secretase inhibitors (GSIs) are found potential to slow the deterioration of various types of cancer recent studies revealed. Now further study for more accurate information about this application is undergoing, in which different cancer types are involve... Read More

Some vaccines support evolution of more-virulent viruses

Scientific experiments with the herpesvirus such as the one that causes Marek's disease in poultry have confirmed, for the first time, the highly controversial theory that some vaccines could allow more-virulent versions of a virus to survive, putting unvaccinated individuals at greater risk of ... Read More

3 ANTIBIOTICS GANG UP TO KILL DEADLY STAPH

As a trio, three antibiotics that aren’t individually effective against a drug-resistant staph infection killed the deadly pathogen in test tubes and mice. Read More

Nobel Prize in Physiology or Medicine was Shared by Three Scientists

BOC Sciences-The three scientists who were awarded for the Noble Prize in Physiology or Medicine were all born in the 30’s of last century. They made the breakthrough both in their own scientific career and on the way of drug development for the whole humankind partly because of the spirit of pe... Read More

Paper-based test can quickly diagnose Ebola in remote areas (video)

BOSTON, Aug. 18, 2015 -- When a fever strikes in a developing area, the immediate concern may be: Is it the common flu or something much worse that requires quarantine? To facilitate diagnosis in remote, low-resource settings, researchers have developed a paper-based device that changes color, d... Read More

Strategies to decrease bacterial colonization

Among the bacterial infections that are most difficult to treat, chronic infections associated with bacterial biofilms are one of the most hazardous. Bacterial biofilms are densely packed communities of microbial cells surrounded with secreted polymers. In her doctoral thesis, chemist Shoghik Ha... Read More
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