Described as the “Most Beautiful Experiment In Biology” the demonstration by Meselson and Stahl that DNA replicates semiconservatively is one of the major landmarks in the genesis of modern biology. And indeed it is most pleasing, both visually and cerebrally.
By semiconservative is meant tha... Read More
Scientists in Canada have developed a paper-based device that checks if bacteria are resistant to certain antibiotics. The simple system could help users in remote areas pick the most appropriate treatment for bacterial infections.
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On the continental margins, where the seafloor drops hundreds of meters below the water’s surface, low temperatures and high pressure lock methane inside ice crystals. Called methane hydrates, these crystals are a potential energy source, but they are also a potential source of global warming if... Read More
Over a number of years, epidemiological studies established several well-defined risk factors for cancer, including age, heredity, diet, tobacco use, chronic viral infections, and inflammation. Paradoxically, the success of these studies left little room for incorporation of any new factors or c... Read More
Harvard stem cells scientists at Brigham and Women’s Hospital and MIT can now engineer cells that are more easily controlled following transplantation, potentially making cell therapies, hundreds of which are currently in clinical trials across the United States, more functional and efficient.
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Communities in Africa and Thailand that worked together on HIV-prevention efforts saw not only a rise in HIV screening but a drop in new infections, according to a new study in the peer-reviewed journal The Lancet Global Health.
The U.S. National Institute of Mental Health's Project Accept —... Read More
Viruses are the most abundant biological entities on the planet with approximately 1030 in the world’s oceans at any time. As such, they play a central role in global nutrient cycling. Despite their ecological importance, little is known about how viruses interact with their hosts due to the dif... Read More
Influenza infection can enhance the ability of the bacterium Streptococcus pneumoniae to cause ear and throat infections, according to research published ahead of print in the journal Infection and Immunity.
In the study, the investigators infected mice with either influenza alone, pneumococc... Read More
(Re-)Introducing the Pseudomonads. Despite the somewhat murky provenance of their name, pseudomonads are everything but "pseudo-" in terms of their metabolic versatility: they are bacterial omnivores, heterotrophs yet far from picky. Members of the family Pseudomonadaceae (Gammaproteobacteria) a... Read More
Single-cell genomics could provide new insight into the biology of malaria parasites (including their virulence and levels of drug resistance) to ultimately improve treatment and control of the disease, according to new research funded by the Wellcome Trust and the National Institutes of Health.... Read More
An international team of scientists from Singapore, Thailand, China and Australia has cracked the genetic code of the liver fluke parasite, Opisthorchis viverrini, using a unique DNA analysis technique developed at A*STAR’s Genome Institute of Singapore (GIS).
GIS’s DNA analysis technique ha... Read More
In May 1984, readers of an article by Schwartz and Cantor in the prestigious journal Cell were to stumble upon pictures of DNA agarose gels that were among the lousiest of such ever published after the method was introduced in the early 70s. Why did the editors of Cell risk their reputation? Or ... Read More
Researchers at UCL have developed a new antibacterial material which has potential for cutting hospital acquired infections. The combination of two simple dyes with nanoscopic particles of gold is deadly to bacteria when activated by light - even under modest indoor lighting. And in a first for ... Read More
Recently identified cell-cycle controls are targets for new drugs that fight infections by shutting down division.
A cell is not a soap bubble that can simply pinch in two to reproduce. The ability to faithfully copy genetic material and distribute it equally to daughter cells is fundamental ... Read More
Pathogenic fungi like Candida albicans can cause oral, skin, nail and genital infections. While exposure to pathogenic fungi is generally not life-threatening, it can be deadly to immunocompromised patients with AIDS or cancer. A variety of antifungal medications, such as triazoles and polyenes,... Read More
The Amazon river is the largest river in the world. It drains the entire Amazon rainforest, sending leftover nutrients, detritus, and minerals from the South American jungle out into the tropical Atlantic ocean. This runoff forms a freshwater plume, hundreds of miles across, that profoundly affe... Read More
A new study reveals that a protein of the Ebola virus can transform into three distinct shapes, each with a separate function that is critical to the virus's survival. Each shape offers a potential target for developing drugs against Ebola virus disease, a hemorrhagic fever that kills up to 9 ou... Read More
Scientists have announced that for the first time, they have determined the precise atomic structure of the Hepatitis A virus. In an unprecedented step forward, a team of scientists from Beijing and Oxford have been able to map the exact construction of Hepatitis A, down to the individual atoms.... Read More
The world of lipids does not always gets its due. Their oleaginous charm is not always appreciated, as we said here before. For example, have you heard of hopanoids? They are made by some bacteria and are an unusual kind of polycyclic lipids that resemble steroids, but with an extra ring. Just l... Read More
A still somewhat unfamiliar term is floating around: the pan-genome. In 2005, Tettelin et al. coined the term along with genome analyses of eight Streptococcus agalactiae strains, and Merry introduced it to this blog, some time back already. Today, a keyword search in PubMed returns roughly 200 ... Read More