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Burkholderia multivorans evolves in bursts in the lungs of cystic fibrosis patients

Leonilde M. Moreira, PhD, has been studying the Burkholderia complex for 15 years. The bacteria, known for causing pneumonia or septicemia in some individuals, can survive for prolonged periods in moist environments. During the last 10 years, it has become one of the more predominant bacteria se... Read More

Vibrio cholerae population structure changes in a matter of weeks

Although the Gram-negative bacterium Vibrio cholerae (right) is normally associated with human pathogenic disease, most V. cholerae cells spend their lives in an aquatic environment, and only a few of the many serotypes are able to cause disease. When strains acquire the right genetic makeup – s... Read More

TWiM #141: Nutritional immunity and polymicrobial infections

Jennifer joins Vincent, Elio, and Michael to talk about the work of her laboratory on how a respiratory virus enhances bacterial growth by dysregulating nutritional immunity.


Hosts: Vincent Racaniello, ... Read More

BacterioFiles 268 - Sophisticated Cyanobacterium Sight

This episode: Spherical cyanobacterium Synechocystis acts like a tiny eyeball in sensing light, allowing cells to move closer to light sources!


(9.7 MB, 10.6 minutes)


Show notes: synSEM Read More

Investigators Map Genomes of Three Historically Important Zika Strains

Washington, DC - August 18, 2016 - A team of researchers from Utah State University, Logan, has characterized the consensus genome sequences of three historically important Zika virus strains. This work is an important step towards developing antiviral therapeutic and preventive strategies again... Read More

TWiM 135 Letters

Reed writes:


Dear Vincent, Elio, Michael, and Michelle,


I've just recently finished TWiM number 133 and wanted to comment about the use of the term "secondary metabolite" throughout the episode and often in the primary literature. Michael pointed out that a se... Read More

Carbapenem-resistant bacteria isolated from a pig farm in the United States

While carbapenems aren’t allowed to be given to feedlot animals, other beta-lactam antibiotics are. This is a large class of drugs that includes extended-spectrum cephalosporin drugs. There is no direct line between the use of these extended-spectrum cephalosporins and selection for carbapenem r... Read More

BacterioFiles 284 - Remedies Reduce Recipient Rejection

This episode: Modifying mice's microbial communities increased mouse survival before a transplantation was rejected by their immune system!


(9.6 MB, 10.5 minutes)


Show notes: 


Read More

Are Viruses Alive?

Plenty of people have weighed in on the question, 'Are Viruses Alive?' Here is my answer - different from all the others. Read More

Zika virus in Brazilian non-human primates

Zika virus RNA has been detected in New World monkeys from the Northeast region of Brazil. This finding suggests that primates may serve as a reservoir host for the virus, as occurs in Africa. Read More

TWiV 416: Scattered seeds dormant

The multi-dimensional TWiV-brane brings you the entries in the haiku/limerick contest, and explain how a giant virus infects a host within another host (it has to do with predators!).


Hosts:  Read More

Assessing gram stain error rates

Because of its simplicity and the rapid time-to-result turnaround, gram staining plays an important role in clinical microbiology. Learning the cell structure helps eliminate potential disease etiologies: learning an isolate is a gram-negative rod doesn’t tell you what the diagnosis is, but it h... Read More

TWiV 429: Zika Experimental Science Team

Vincent meets with members of team ZEST at the University of Wisconsin Madison to discuss their macaque model for Zika virus pathogenesis.


Hosts: Vincent Racaniello Read More

Yeast fights viruses!

Humans have used Saccharomyces cerevisiae yeast in baking, brewing and winemaking for millennia. New research from the University of Idaho and the University of Colorado Boulder reveals another way that yeast species can help our species: by demonstrating how viruses interact with their hosts, a... Read More

TWiV Special: DA Henderson, smallpox eradicator

Donald “D.A.” Henderson, a physician, educator, and epidemiologist who led the World Health Organization’s campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox era... Read More

THE RIDDLE OF THE R.I.D.L _ Zika virus Comics (Playlist)

In Zanzare, the new comic from Cimaza (www.cimazacomics.com/), we are plunged head-first into the global mystery of the Zika virus. We meet the mosquitoes (in Italian: zanzare) implicated in its spread; but the insects plead their innocence, saying it's all a misunderstanding. They lay their cas... Read More

BacterioFiles 267 - Crust Color Cooks Communities

This episode: Cyanobacteria in biocrusts produce pigments that heat their surroundings up to 10 degrees hotter!


(7 MB, 7.6 minutes)


Show notes: 
Read More

TWiV 404: Not found

From the twiVivants, follow up on FluMist and Zoster vaccines, Zika virus update, and isolation of a multicomponent animal virus from mosquitoes.


Hosts: Vincent Racaniello Read More

BOROBODUR Temple

This artwork is made from Escherechia coli in Mac Conkey Agar ( MCA ) and shows the other side of the biggest Buddhist temple in Indonesia and Southeast Asia built by the Syailendra dynasty called “Borobudur”, that included one of the wonders of the world from Indonesia.

Read More

Dispatches from ASM Microbe - Sunday

We’ve had a whirlwind of amazing talks, poster sessions, and networking sessions so far at ASM Microbe 2016. In our previous two Dispatches from ASM Microbe, we’ve covered microbiomes, for which research ranges from extremely basic (Which microbes are present? How do we quantify them?) to clinic... Read More
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