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Professor, graduate student unravel mystery of bacteria's antibiotic resistance

A popular antibiotic called rifampicin, used to treat tuberculosis, leprosy, and Legionnaire’s disease, is becoming less effective as the bacteria that cause the diseases develop more resistance.

One of the mechanisms leading to rifampicin’s resistance is the action of the enzyme Rifampicin m... Read More

Close Quarters: The Importance of Interspecies Interactions in Microbial Biofilms

Biofilms, surface-attached microbial communities encased in an extracellular matrix, are one of the most common macroscopic microbial structures we can see in nature. Biofilms like those seen in pond scum, in dental plaque, or in hot springs, are mixed communities with the members forming both a... Read More

Seeking understanding of the bacterial sec system

How do bacterial proteins destined for export move from inside to outside the cell? As mBiosphere readers may know, there are a number of secretion systems that bacteria use to move materials from inside the cell to outside the cell. Some of these systems, such as the Sec secretion system, are c... Read More

TWiV 409: A Nef is enough

Jeremy joins the TWiVeroids to tell the amazing story of how the function of the HIV-1 protein called Nef was discovered and found to promote infection by excluding the host protein SERINC from virus particles.

Hosts:  Read More

Dr House goes digital as IBM’s Watson diagnoses rare diseases

Medics charged with diagnosing the kind of extremely rare diseases that Hugh Laurie’s consultant routinely spots in TV drama House have found that artificial intelligence can do a similar job – but in seconds rather than days or weeks.

From December, doctors at the University Hospital of Marb... Read More

Scientists Identify Potential Antivirals Against Chikungunya

Chikungunya virus has caused two recent massive outbreaks sickening millions of people. Now a team of researchers has shown that several existing compounds have potent activity against the critical CHIKV protease enzyme. The research is published October 10 in Antimicrobial Agents and Chemothera... Read More

New, carbon-nanotube tool for ultra-sensitive virus detection and identification

A new tool that uses a forest-like array of vertically-aligned carbon nanotubes that can be finely tuned to selectively trap viruses by their size can increase the detection threshold for viruses and speed the process of identifying newly-emerging viruses.

"Early detection is important becau... Read More

World's first dengue fever vaccine launched in the Philippines

Dengue fever infects 390 million people each year, and kills as many as 25,000, according to the World Health Organization.

The disease could soon see these numbers decline as the Philippines start administering the world's first dengue vaccine to high-risk children.

The historic drug took... Read More

S. mutants mutation increases fluoride resistance

Microbes are excellent at adapting to stressful situations, which is part of the reason antibiotic resistance is a problem today. Constant exposure to antimicrobials such as triclosan have selected for resistant strains, rendering the compound ineffective. This is why the FDA recently banned t... Read More

Antimicrobial resistance gene found in marine pathogen

A team of Chinese investigators has discovered a gene for resistance to β-lactamase antibiotics, in the pathogenic marine bacterium, Vibrio parahaemolyticus. The β-lactamase gene, blaVEB-2, has never before been found in V. parahaemolyticus, and in fact, has been found almost exclusively in non-... Read More

A promising step toward controlling Zika virus and dengue fever

Five UCLA researchers were part of an international team that has used X-rays to reveal the structure of a molecule that is toxic to disease-carrying mosquitoes. The findings move the scientific world one step closer to genetically engineering a toxin that would be lethal to species that carry d... Read More

CMV Is a Greater Threat to Infants Than Zika, but Far Less Often Discussed

The world has been galvanized by the Zika epidemic spreading through the Americas, which has left more than two thousand infants with severe brain damage. But for pregnant women and their infants in the United States, cytomegalovirus, or CMV, is the far greater viral threat.

Every year, 20,00... Read More

Grand Challenge: Mapping the Human Immune System

A team of scientists has created a genetic map of all possible receptors the human immune system might generate—also known as the immunome.

The project involved a mind-boggling data set.

“If we were on a treasure hunt, where the cure to many illnesses is the buried treasure, then we’ve jus... Read More

Organism mix on a hand print

Mix of organism seen on a handprint/finger on TSA after incubation at 37 degrees for 24 hrs then held at refrigerated temperatures for 1 month. Read More

Zika likely to spread in Asia Pacific: WHO

The Zika virus is set to spread through Asia, the World Health Organization warned Monday, with hundreds of cases reported in Singapore and two Thai babies diagnosed with Zika-linked microcephaly.

The mosquito-borne virus has been detected in 70 countries worldwide including at least 19 count... Read More

Zika virus infection may prevent reinfection, collaborative study finds

People infected with Zika virus may not be susceptible to Zika virus again, according to the latest research involving Kansas State University's Biosecurity Research Institute.

"The research shows that infection provides excellent protection against reinfection," said Stephen Higgs, director ... Read More

Microbes in the breast may play a role in breast cancer

The gut microbiome has stolen the show when it comes to the recent explosion of research on the bacteria that thrive within us. But bacteria also live in a woman's breast tissue—and the mix of those microbes may have an equally important effect on health, according to a new study in Applied and ... Read More

How cells take out the trash—phosphoarginine deciphered

Cells never forget to take out the trash. It has long been known that cells tag proteins for degradation by labelling them with ubiquitin, a signal described as "the molecular kiss of death". Tim Clausen's group at the Research Institute of Molecular Pathology (IMP) in Vienna identified an analo... Read More

Scientists Uncover Why Hepatitis C Virus Vaccine Has Been Difficult to Make

Researchers have been trying for decades to develop a vaccine against the globally endemic hepatitis C virus (HCV). Now scientists at The Scripps Research Institute (TSRI) have discovered one reason why success has so far been elusive.

Using a sophisticated array of techniques for mapping tin... Read More

Autophagy, Illustrated (infographic)

Earlier this week, Yoshinori Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his work on the underlying mechanisms of autophagy—the process by which cells break down and recycle their own contents. How does autophagy work? Here are the basics, as drawn for the article “How ... Read More
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