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Preclinical Studies on the Pharmacokinetics, Safety, and Toxicology of Oxfendazole: Toward First in Human Studies

A number of BZ anthelmintics used in veterinary medicine have been considered for transition to human use, including oxibendazole and oxfendazole (OXF). In addition, flubendazole, already approved for use as an intestinal anthelmintic, is also being developed as a treatment against adult filaria... Read More

BacterioFiles 277 - Sailor Cells Store Selenium

This episode: Bacteria with their own magnetic compass can also clean up and recover toxic but valuable elements!


(6.1 MB, 6.7 minutes)


Show notes: 


Read More

TWiV Special: DA Henderson, smallpox eradicator

Donald “D.A.” Henderson, a physician, educator, and epidemiologist who led the World Health Organization’s campaign to eradicate smallpox, died at 87 years of age on Aug. 19, 2016. Vincent was fortunate to have the opportunity to speak with DA Henderson in 2014 about his career, the smallpox era... Read More

TWiM 135 Letters

Reed writes:


Dear Vincent, Elio, Michael, and Michelle,


I've just recently finished TWiM number 133 and wanted to comment about the use of the term "secondary metabolite" throughout the episode and often in the primary literature. Michael pointed out that a se... Read More

MWV 106 - This Week in Virology: Boston Quammens

Four years to the day after filming 'Threading the NEIDL', Vincent and Alan return to the National Emerging Infectious Diseases Laboratories BSL4 facility at Boston University where they speak with science writer David Quammen during the Emerging Infectious Disea... Read More

A microbial mystery in the Namib Desert

The Namib Desert is different than other deserts: it has an unusual geographic feature that differentiates it from most others. This desert (map, right) is where you can find ‘fairy circles,’ or circular areas absent of growth in an already plant-scarce environment. These deadened circles are su... Read More

Dispatches from ASM Microbe - Sunday

We’ve had a whirlwind of amazing talks, poster sessions, and networking sessions so far at ASM Microbe 2016. In our previous two Dispatches from ASM Microbe, we’ve covered microbiomes, for which research ranges from extremely basic (Which microbes are present? How do we quantify them?) to clinic... Read More

BacterioFiles 269 - Magnetic Microbes Maim MRSA

This episode: Killing pathogens by attaching magnetotactic bacteria to them and then raising the heat with magnetic fields!


(10.6 MB, 11.6 minutes)


Show notes: 


Journal Paper:
Chen C, Chen L, Yi Y, Chen C, Wu L-F, Song ... Read More

Study Shows How Bacteria Evolve in the Lungs of Cystic Fibrosis Patients

Washington, DC – May 24, 2016 – The bacterium Burkholderia multivorans evolves and adapts in bursts to survive in the lungs of cystic fibrosis patients, according to a study published this week in mSystems, an open access journal from the American Society for Microbiology. The work, believed to ... Read More

Top secret, viruses with RNA genomes!

Today it is well known that viruses may contain DNA (poxvirus, mimivirus) or RNA (influenza virus, Zika virus), but for many years it was thought that genomes were only made of DNA. The surprise at finding only RNA in a virus is plainly evident in a 1953 letter from Harriett Ephrussi-Taylor to J... Read More

TWiV 402: The plight of the bumblebee

Polio returns to Nigeria, Zika virus spreads in Miami, and virus infection of plants attracts bumblebees for pollination, from the virus gentlepeople at TWiV.


Hosts: Vincent Racaniello Read More

Zika virus infects human neural stem cells

The Zika virus infects a type of neural stem cell that gives rise to the brain's cerebral cortex, Johns Hopkins and Florida State researchers report March 4 in Cell Stem Cell. On laboratory dishes, these stem cells were found to be havens for viral reproduction, resulting in cell death and/or di... Read More

Serratia marcescens

The image of Red Lord Ganesha on this MacConkey agar plate is made of Serratia marcescens. It is just an expression that microorganisms are ubiquitous and miraculous in nature just as our gods.
Serratia marcescens produces a blood red pigment called prodigiosin (latin word prodigiosus meaning ... Read More

MWV 107 - The Necrobiome: Microbial Life After Death

What happens to us after we die?  A decomposing corpse becomes its own mini-ecosystem, hosting insects, scavengers and multitudes of microbes.  Microbes from the environment, the corpse, as well as the insects and scavengers are blended together and work to recycle tissues back to t... Read More

Magnetotactic bacteria remove and recover rare elements

While our human biochemical reactions are limited, our ingenuity is not, and scientists are able to exploit microbes for our benefit, such as in chemical spills. Using microbes to degrade or sequester toxic molecules is one form of bioremediation, and has many various applications. Famously, sci... Read More

A role for siderophores in Klebsiella pneumoniae pathogenesis

Despite increasing awareness of Klebsiella pneumoniae as a public health risk, there has been relatively little understood about its mechanisms of pathogenesis.

The bacterium, estimated to be the third most common cause of hospital-acquired infections in the United States in a recent study, c... Read More

Zika virus, like all other viruses, is mutating

Not long after the appearance of an outbreak of viral disease, first scientists, and then newswriters, blame it all on mutation of the virus. It happened during the Ebolavirus outbreak in West Africa, and now it’s happening with Zika virus.

The latest example is by parasitologist Peter Hotez,... Read More

BacterioFiles 268 - Sophisticated Cyanobacterium Sight

This episode: Spherical cyanobacterium Synechocystis acts like a tiny eyeball in sensing light, allowing cells to move closer to light sources!


(9.7 MB, 10.6 minutes)


Show notes: synSEM Read More

Diverse fungi inhabit chronic wounds and inhibit healing

Gruesome, ghastly, grisly. These are the words that popped into my head when I googled images of diabetic foot ulcers—one of the most common chronic wounds creating a silent and costly epidemic in healthcare.

Perhaps even more shocking is the mortality rate connected to these open wounds, wh... Read More

TWiV 413: Partnerships not Parachutes

From the EIDA2Z conference at Boston University, Vincent, Alan and Paul meet up with Ralph Baric, Felix Drexler, Marion Koopmans, and Stacey Schultz-Cherry to talk about discovering, understanding, protecting, and collaborating on emerging infectious diseases.


Hosts:  Read More

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