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The Bacterial Chromosome: A Physical Biologist's Apology. A Perspective.

I entered the bacterial chromosome field in 2004 as a fresh Ph.D. trained in theoretical physics. Ten years is not long enough for one to gain the depth and breadth of a scientific discipline of long history, certainly not for an early career scientist to write an essay of the status of A Mathem... Read More

Scientists Study What to Do If You Drop a Cookie on the Floor

Once again, you've dropped your snack. You bend down, snatch it up, and gently blow off any dust—and, you hope, deadly germs. You're about to put it in your mouth because, after all, you've got the "five-second rule" on your side: Food that's been dropped is safe to consume if it's been on the f... Read More

TWiV 276: Ramblers go viral



 Host: Vincent Racaniello


Guests: Sus... Read More

Beauty of Ecoli colony in EMB plate

Ecoli isolated from food sample in our laboratory Read More

Fighting for oral dominance: Good fungi keep bad ones in check in healthy mouths

Human mouths contain a balanced mix of microbes which, when disrupted, can lead to oral diseases. A study published on March 13th in PLOS Pathogens compares the bacteria and fungi present in the mouths of healthy individuals with those from patients infected with HIV, and illustrates why oral ca... Read More

Immune Cells Need Each Other to Combat Deadly Lung-Invading Fungus

Although long recognized as an essential defense against the lung-invading fungus Asperfillus fumigatus, Neutrophils actually require a little help from fellow immune cells, according to a study by Amariliz Rivera, her colleagues at Rutgers New Jersey Medical School and scientists at the Fred Hu... Read More

Virtual bees help to unravel microbial and other causes of colony decline

What effect does the varroa mite, and the viruses it transmits, have on bee colonies? To find out, scientists have developed a new computer model to that simulates a honey bee colony over the course of several years.
Shown in the video on this page, the BEEHAVE model was c0-funded by BBSRC and... Read More

Gut bacteria may be best defense against nasty germs

Antibiotic-resistant bacteria are on the rise, making it more and more difficult to treat infections. But research suggests that the best defense against harmful bugs could be a healthy population of “good” gut bacteria. The human relationship with microbial life is complicated. At almost any su... Read More

What’s eating you? The first food web inside humans suggests potential new treatments for infection

Imagine going to the doctor with an infection and being sent home with a course of drugs. Unknown to your doctor you actually have two infections. If you take the drugs will the other infection go away by itself? What if you take the drugs and the other infection gets worse? This quandary faces ... Read More

A New Future for Anti-viral Therapy

Extramural basic research at the Mount Sinai School of Medicine, funded by the U.S. Army Research Laboratory – Army Research Office (ARL-ARO), has led to discoveries of the biochemical mechanisms for viral growth and of an unprecedented method that may inhibit viral replication. These fundamenta... Read More

Commonly used pain relievers have added benefit of fighting bacterial infection

Some commonly used drugs that combat aches and pains, fever, and inflammation are also thought to have the ability to kill bacteria. New research reveals that these drugs, better known as nonsteroidal anti-inflammatory drugs, act on bacteria in a way that is fundamentally different from current ... Read More

Molecule Plays Important Role in Triggering Immune Response

The nucleoside adenosine—a tiny chemical structure made up of a simple base linked to a sugar—is critical for the regulation of bodily functions ranging from blood flow to tissue repair to sleep. Now, researchers at Rutgers New Jersey Medical School show that adenosine is essential in promoti... Read More

Battling Infection With Microbes

The human relationship with microbial life is complicated. At almost any supermarket, you can pick up both antibacterial soap and probiotic yogurt during the same shopping trip. Although there are types of bacteria that can make us sick, Caltech professor of biology and biological engineering Sa... Read More

Bacterium and Fungus Team Up to Cause Virulent Tooth Decay in Toddlers

Early childhood caries, a highly aggressive and painful form of tooth decay that frequently occurs in preschool children, especially from backgrounds of poverty, may result from a nefarious partnership between a bacterium and a fungus, according to a paper published ahead of print in the journal... Read More

TWiM #74: It came from the Siberian permafrost

Hosts: Vincent RacanielloElio Schaechter, and Michael Schmidt


Vin... Read More

TWiM 74 Letters

Katja writes:


Thank you for the great podcast! You've explained our story very well and it was funny to listen to it. I didn't know that "Speak friend and enter" is from lord of the rings! I just wanted to explain the name CYCLOPS because this was a question mark in t... Read More

How a Common Fungus Is Protecting the Earth from a Climate Change Nightmare

There is more carbon dioxide stored in the ground than in the air around us. If those all that greenhouse gas escapes, it could be catastrophic for the earth. Now, a researcher at the University of Texas at Austin thinks he’s found the key that keeps much of it locked away. It’s research that co... Read More

Mix Of Gut Microbes May Play Role In Crohn's Disease

More than a million Americans suffer from Crohn's, which seems to start when an overreactive immune system causes abdominal pain, diarrhea, bleeding, weight loss and other symptoms. Many patients have to take powerful steroids (which can have serious side effects), and some have parts of the dig... Read More

Attenuated influenza vaccine enhances bacterial colonization of mice

Infection with influenza virus is known to increase susceptibility to bacterial infections of the respiratory tract. In a mouse model of influenza, increased bacterial colonization was also observed after administration of an infectious, attenuated influenza virus vaccine. Primary influenza viru... Read More

Breathing New Life into DNA Microarrays

DNA microarrays are widely used in biological research and were once thought to be a very promising gene discovery tool. However, since the advent of next generation DNA sequencing, the popularity of DNA microarrays has steadily declined. Compared to the sequencing, microarray behavior is unce... Read More

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