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TWiP 55: A ladybird's weapon



Hosts: Vincent Racaniello and Dickson Despommier


Vincent and Dickson reveal... Read More

Bioluminescent art: Beautiful bacteria glow in the dark

Bioluminescent art blends science and creativity to create images that can only be seen in the dark. What do you get when you add a chemical engineer, a graphic designer and a research scientist? Beautiful art. In a wondrous combination of nature and design, bioluminescent art involves using nat... Read More

HIV and ‘hot spring’ virus hijack same protein

There’s a surprising connection between HIV, Ebola, and viruses that infect organisms called archaea that grow in volcanic hot springs.

The viruses hijack the same set of proteins to break out of infected cells, new research shows.

In eukaryotes—the group that includes plants and animals—a... Read More

A potential new target to thwart antibiotic resistance

Viruses in gut confer antibiotic resistance to bacteria. Bacteria in the gut that are under attack by antibiotics have allies no one had anticipated, a team of Wyss Institute scientists has found. Gut viruses that usually commandeer the bacteria, it turns out, enable them to survive the antibiot... Read More

BacterioFiles Special Edition - ASM2013 General Meeting Day 3

Here's my summary of the third day of ASM2013, wherein I met with neat people and ideas.




Download Episode Read More

Be gone, bacteria

UI-led team creates first comprehensive guidelines to reduce staph infections after surgery. Staph infections in hospitals are a serious concern, so much so that the term Methicillin-resistant Staphylococcus aureus (MRSA) is as commonly known as MRI. Far less known is that in many of these cases... Read More

Single cells: Same same but different

If half of a cell population were coloured white and the other half were coloured black, scientists should think all cells are grey. Conventional methods average over thousands of cells, overlooking any cell-to-cell variability. ETH scientists now measured metabolite levels in single yeast cells... Read More

Fine Reading: The gut microbiota of insects – diversity in structure and function

Now that the mammalian intestinal microbiome has been promoted to organ status, might not such stately respectability be granted to the gut microbiota of other metazoans? If looking for a worthy candidate for such recognition, one could not do better than to consider the varied communities dwell... Read More

Supreme Court Strikes Down Human Gene Patents

The Supreme Court said human genes isolated by scientists may not be patented, ruling unanimously today in a dispute weighing intellectual property associated with genes known to detect early signs of breast and ovarian cancer.

The dispute concerned a 2009 lawsuit filed by the American Civil ... Read More

FDA gets to grips with faeces

Regulator triggers efforts to standardize faecal transplants. The brown slurry is piped through tubes into the top of the human body — or the bottom. It can even come in pill form. For years, doctors have been transferring faeces into ill people’s intestines to replace resident microbes with a f... Read More

Viral Architecture

Seeing how the Hepatitis C virus builds ion channels could help researchers find new drugs to fight the disease. Viruses are masters of minimalist design. With only a simple genome and a handful of proteins, a virus can hijack much more sophisticated cells and mimic many of the intra- and inter-... Read More

Nasty toxin helps E. coli survive in water

Strains of E. coli that produce the Shiga toxin last longer in lake water. The toxin appears to help E. coli fend off predators. “The take-home lesson is that E. coli that produce Shiga toxin persisted longer in recreational water than E. coli that don’t produce this toxin,” says study leader Ge... Read More

TWiP 55 letters

Jessie writes:


Hi Vince and Dick!


Has anyone volunteered to do transcripts for TWIP? I love this show, and I'd love to be able to contribute in some way. Forgive me if transcripts already exist and I'm just not finding them on the website. If no one is already... Read More

'Chase and Run' Cell Movement Mechanism Explains Process of Metastasis

A mechanism that cells use to group together and move around the body -- called 'chase and run' -- has been described for the first time by scientists at UCL. Published in Nature Cell Biology, the new study focuses on the process that occurs when cancer cells interact with healthy cells in order... Read More

Study builds dossier on JC polyomavirus

A new study shows that common mutant forms of the deadly JC polyomavirus are not responsible for the pathogen’s main attack, which causes a brain-damaging disease in immunocompromised patients called progressive multifocal leukoencephalopathy. But that finding raises the ominous question of what... Read More

Virus That Evolved in the Lab Delivers Gene Therapy into the Retina

From millions of random mutations, scientists identify a virus that could make gene therapy for inherited retinal diseases safer and more effective. A new delivery mechanism shuttles gene therapy deep into the eye’s retina to repair damaged light-sensing cells without requiring a surgeon to put ... Read More

TWiV 237: Paleovirology with Michael Emerman



Hosts: Vincent Racaniello and Rich Condit Read More

Father-Son Duo Reinvent Drug Testing With ‘Digital Lab Rats’

In 2008, François-Henri Boissel was leading a charmed life. He was a young, successful investment banker working in Tokyo, Japan. And then the market crashed.

He thought of sticking it out, waiting until things improved, but then he remembered a conversation he’d had with his father, Jean-Pie... Read More

New virus discovered in patients with central nervous system infections: an infection from livestock?

Patients in Vietnam and other locations with central nervous system infections may well be suffering from the effects of a newly discovered virus. Researchers have detected a virus they're calling CyCV-VN in spinal fluid from 4% of 642 patients with central nervous system infections of unknown c... Read More

Scientists reconstruct the genome of medieval strains of the pathogen responsible for leprosy

Why was there a sudden drop in the incidence of leprosy at the end of the Middle Ages? To answer this question, biologists and archeologists reconstructed the genomes of medieval strains of the pathogen responsible for the disease, which they exhumed from centuries old human graves. Their result... Read More
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